Iron removal from transferrin An experimental study

Simeon Pollack, Grace Vanderhoff, Fred Lasky

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

We have studied the facilitation of iron transfer from transferrin to desferrioxamine by various anions. Most of the anions which can substitute for HCO3- in the ternary complex of transferrin · Fe · HCO3 do not facilitate iron transfer; anions which do facilitate iron transfer do not necessarily form stable ternary complexes. Combinations of anions effective in transfer have a less-than-additive effect, suggesting a common reaction pathway. We suggest that the transfer of iron from transferrin to desferrioxamine involves a substitution step and a subsequent chelation step, and that the efficiency of the overall reaction is a function of both these attributes of the anion.

Original languageEnglish (US)
Pages (from-to)481-487
Number of pages7
JournalBBA - General Subjects
Volume497
Issue number2
DOIs
StatePublished - Apr 27 1977

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Transferrin
Anions
Iron
Deferoxamine
Chelation
Substitution reactions

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology
  • Medicine(all)

Cite this

Iron removal from transferrin An experimental study. / Pollack, Simeon; Vanderhoff, Grace; Lasky, Fred.

In: BBA - General Subjects, Vol. 497, No. 2, 27.04.1977, p. 481-487.

Research output: Contribution to journalArticle

Pollack, Simeon ; Vanderhoff, Grace ; Lasky, Fred. / Iron removal from transferrin An experimental study. In: BBA - General Subjects. 1977 ; Vol. 497, No. 2. pp. 481-487.
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