TY - JOUR
T1 - Iron removal from transferrin An experimental study
AU - Pollack, Simeon
AU - Vanderhoff, Grace
AU - Lasky, Fred
N1 - Funding Information:
This work was supported by the Cooleys Anemia Foundation.
PY - 1977/4/27
Y1 - 1977/4/27
N2 - We have studied the facilitation of iron transfer from transferrin to desferrioxamine by various anions. Most of the anions which can substitute for HCO3- in the ternary complex of transferrin · Fe · HCO3 do not facilitate iron transfer; anions which do facilitate iron transfer do not necessarily form stable ternary complexes. Combinations of anions effective in transfer have a less-than-additive effect, suggesting a common reaction pathway. We suggest that the transfer of iron from transferrin to desferrioxamine involves a substitution step and a subsequent chelation step, and that the efficiency of the overall reaction is a function of both these attributes of the anion.
AB - We have studied the facilitation of iron transfer from transferrin to desferrioxamine by various anions. Most of the anions which can substitute for HCO3- in the ternary complex of transferrin · Fe · HCO3 do not facilitate iron transfer; anions which do facilitate iron transfer do not necessarily form stable ternary complexes. Combinations of anions effective in transfer have a less-than-additive effect, suggesting a common reaction pathway. We suggest that the transfer of iron from transferrin to desferrioxamine involves a substitution step and a subsequent chelation step, and that the efficiency of the overall reaction is a function of both these attributes of the anion.
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U2 - 10.1016/0304-4165(77)90205-7
DO - 10.1016/0304-4165(77)90205-7
M3 - Article
C2 - 870073
AN - SCOPUS:0017344129
SN - 0304-4165
VL - 497
SP - 481
EP - 487
JO - BBA - General Subjects
JF - BBA - General Subjects
IS - 2
ER -