Iron removal from transferrin An experimental study

Simeon Pollack, Grace Vanderhoff, Fred Lasky

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Abstract

We have studied the facilitation of iron transfer from transferrin to desferrioxamine by various anions. Most of the anions which can substitute for HCO3- in the ternary complex of transferrin · Fe · HCO3 do not facilitate iron transfer; anions which do facilitate iron transfer do not necessarily form stable ternary complexes. Combinations of anions effective in transfer have a less-than-additive effect, suggesting a common reaction pathway. We suggest that the transfer of iron from transferrin to desferrioxamine involves a substitution step and a subsequent chelation step, and that the efficiency of the overall reaction is a function of both these attributes of the anion.

Original languageEnglish (US)
Pages (from-to)481-487
Number of pages7
JournalBBA - General Subjects
Volume497
Issue number2
DOIs
Publication statusPublished - Apr 27 1977

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ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology

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