Iron-dependent lysosomal dysfunction mediated by a natural product hybrid

A. Mariani, T. T. Mai, E. Zacharioudakis, A. Hienzsch, A. Bartoli, T. Cañeque, R. Rodriguez

Research output: Contribution to journalArticlepeer-review

7 Scopus citations


Artesumycin is a fluorescent hybrid of the natural products marmycin A and artemisinin. It was designed to combine the lysosomotropic properties of the angucycline and the iron-reactive capacity of the endoperoxide to target the lysosomal compartment of cancer cells. Herein, we show that artesumycin inhibits cancer cell proliferation in an iron-dependent manner and chemically fragments in vitro in the presence of redox-active iron(ii). Visual detection of artesumycin by fluorescence microscopy provided substantial evidence that the small molecule selectively targets lysosomes. This original approach based on a fluorescent and iron-reactive probe represents a powerful strategy for initiating and, concomitantly, visualizing lysosomal dysfunction in human cells.

Original languageEnglish (US)
Pages (from-to)1358-1360
Number of pages3
JournalChemical Communications
Issue number7
StatePublished - Jan 25 2016
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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