Iron bioavailability and redox activity in diverse carbon nanotube samples

Lin Guo, Daniel G. Morris, Xinyuan Liu, Charles Vaslet, Robert H. Hurt, Agnes B. Kane

Research output: Contribution to journalArticle

122 Citations (Scopus)

Abstract

The ultimate success of many nanotechnologies will depend on our ability to understand and manage nanomaterial health risks. Carbon nanotubes are now primarily fabricated by catalytic routes and typically contain significant quantities of transition metal catalyst residues. Iron-catalyzed free-radical generation has been hypothesized to contribute to oxidative stress and toxicity upon exposure to ambient particulate, amphibole asbestos fibers, and single-wall carbon nanotubes. A key issue surrounding nanotube iron is bioavailability, which has not been systematically characterized, but is widely thought to be low on the basis of electron microscope observations of metal encapsulation by carbon shells. Here, we validate and apply simple acellular assays to show that toxicologically significant amounts of iron can be mobilized from a diverse set of commercial nanotube samples in the presence of ascorbate and the chelating agent ferrozine. This mobilized iron is redox active and induces single-strand breaks in plasmid DNA in the presence of ascorbate. Iron bioavailability varies greatly from sample to sample and cannot be predicted from total iron content. Iron bioavailability is not fully suppressed by vendor "purification" and is sensitive to partial oxidation, mechanical stress, sample age, and intentional chelation. The results suggest practical materials chemistry approaches for anticipating and managing bioavailable iron to minimize carbon nanotube toxicity.

Original languageEnglish (US)
Pages (from-to)3472-3478
Number of pages7
JournalChemistry of Materials
Volume19
Issue number14
DOIs
StatePublished - Jul 10 2007
Externally publishedYes

Fingerprint

Carbon Nanotubes
Carbon nanotubes
Iron
Chelation
Nanotubes
Toxicity
Ferrozine
Amphibole Asbestos
Oxidative stress
Asbestos
Oxidation-Reduction
Biological Availability
Health risks
Chelating Agents
Free radicals
Nanotechnology
Encapsulation
Nanostructured materials
Free Radicals
Transition metals

ASJC Scopus subject areas

  • Materials Chemistry
  • Materials Science(all)

Cite this

Guo, L., Morris, D. G., Liu, X., Vaslet, C., Hurt, R. H., & Kane, A. B. (2007). Iron bioavailability and redox activity in diverse carbon nanotube samples. Chemistry of Materials, 19(14), 3472-3478. https://doi.org/10.1021/cm062691p

Iron bioavailability and redox activity in diverse carbon nanotube samples. / Guo, Lin; Morris, Daniel G.; Liu, Xinyuan; Vaslet, Charles; Hurt, Robert H.; Kane, Agnes B.

In: Chemistry of Materials, Vol. 19, No. 14, 10.07.2007, p. 3472-3478.

Research output: Contribution to journalArticle

Guo, L, Morris, DG, Liu, X, Vaslet, C, Hurt, RH & Kane, AB 2007, 'Iron bioavailability and redox activity in diverse carbon nanotube samples', Chemistry of Materials, vol. 19, no. 14, pp. 3472-3478. https://doi.org/10.1021/cm062691p
Guo L, Morris DG, Liu X, Vaslet C, Hurt RH, Kane AB. Iron bioavailability and redox activity in diverse carbon nanotube samples. Chemistry of Materials. 2007 Jul 10;19(14):3472-3478. https://doi.org/10.1021/cm062691p
Guo, Lin ; Morris, Daniel G. ; Liu, Xinyuan ; Vaslet, Charles ; Hurt, Robert H. ; Kane, Agnes B. / Iron bioavailability and redox activity in diverse carbon nanotube samples. In: Chemistry of Materials. 2007 ; Vol. 19, No. 14. pp. 3472-3478.
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