Ion channels as novel therapeutic targets in heart failure

Fadi G. Akar, Gordon F. Tomaselli

Research output: Contribution to journalReview article

25 Scopus citations

Abstract

Electrophysiological remodeling in heart failure (HF) is characterized by major changes in ion channel function and expression that alter the electrical phenotype and predispose to the development of lethal ventricular tachyarrhythmias. In this article, we provide a review of our current understanding of HF-induced ion channel dysfunction by highlighting changes in potassium and sodium currents, pumps, and exchangers as well as calcium handling proteins. We further relate these changes in ion channel function to abnormalities in impulse generation, conduction, and repolarization with a view towards identifying potentially novel targets for anti-arrhythmic therapy for this public health epidemic.

Original languageEnglish (US)
Pages (from-to)44-54
Number of pages11
JournalAnnals of Medicine
Volume37
Issue number1
DOIs
StatePublished - Mar 21 2005
Externally publishedYes

Keywords

  • Arrhythmias
  • Heart failure
  • Ion channels

ASJC Scopus subject areas

  • Medicine(all)

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