Involvement of the brain stem reticular formation in familial amyotrophic lateral sclerosis

S. Kato, A. Hirano

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The reticular formation of the brain stem of three cases of familial amyotrophic lateral sclerosis (ALS) with posterior column and spinocerebellar tract involvement showed a paucity of large neurons, chromatolytic neurons and Lewy body-like intracytoplasmic inclusions. Some of the remaining neurons were stained focally by antibodies to phosphorylated neurofilaments and ubiquitin; the staining patterns were similar to those seen in anterior horn cells. Within the reticular formation, the medial part of the medulla oblongata was most pronouncedly affected. The reticular formation should be among the systems other than motor neurons that may be involved in this type of familial ALS.

Original languageEnglish (US)
Pages (from-to)41-44
Number of pages4
JournalClinical Neuropathology
Volume11
Issue number1
StatePublished - 1992

Fingerprint

Reticular Formation
Brain Stem
Neurons
Spinocerebellar Tracts
Anterior Horn Cells
Lewy Bodies
Medulla Oblongata
Intermediate Filaments
Motor Neurons
Ubiquitin
Staining and Labeling
Antibodies
Amyotrophic lateral sclerosis 1

ASJC Scopus subject areas

  • Clinical Neurology
  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Involvement of the brain stem reticular formation in familial amyotrophic lateral sclerosis. / Kato, S.; Hirano, A.

In: Clinical Neuropathology, Vol. 11, No. 1, 1992, p. 41-44.

Research output: Contribution to journalArticle

@article{752316790c614afaabd1670238cc62cb,
title = "Involvement of the brain stem reticular formation in familial amyotrophic lateral sclerosis",
abstract = "The reticular formation of the brain stem of three cases of familial amyotrophic lateral sclerosis (ALS) with posterior column and spinocerebellar tract involvement showed a paucity of large neurons, chromatolytic neurons and Lewy body-like intracytoplasmic inclusions. Some of the remaining neurons were stained focally by antibodies to phosphorylated neurofilaments and ubiquitin; the staining patterns were similar to those seen in anterior horn cells. Within the reticular formation, the medial part of the medulla oblongata was most pronouncedly affected. The reticular formation should be among the systems other than motor neurons that may be involved in this type of familial ALS.",
author = "S. Kato and A. Hirano",
year = "1992",
language = "English (US)",
volume = "11",
pages = "41--44",
journal = "Clinical Neuropathology",
issn = "0722-5091",
publisher = "Dustri-Verlag Dr. Karl Feistle",
number = "1",

}

TY - JOUR

T1 - Involvement of the brain stem reticular formation in familial amyotrophic lateral sclerosis

AU - Kato, S.

AU - Hirano, A.

PY - 1992

Y1 - 1992

N2 - The reticular formation of the brain stem of three cases of familial amyotrophic lateral sclerosis (ALS) with posterior column and spinocerebellar tract involvement showed a paucity of large neurons, chromatolytic neurons and Lewy body-like intracytoplasmic inclusions. Some of the remaining neurons were stained focally by antibodies to phosphorylated neurofilaments and ubiquitin; the staining patterns were similar to those seen in anterior horn cells. Within the reticular formation, the medial part of the medulla oblongata was most pronouncedly affected. The reticular formation should be among the systems other than motor neurons that may be involved in this type of familial ALS.

AB - The reticular formation of the brain stem of three cases of familial amyotrophic lateral sclerosis (ALS) with posterior column and spinocerebellar tract involvement showed a paucity of large neurons, chromatolytic neurons and Lewy body-like intracytoplasmic inclusions. Some of the remaining neurons were stained focally by antibodies to phosphorylated neurofilaments and ubiquitin; the staining patterns were similar to those seen in anterior horn cells. Within the reticular formation, the medial part of the medulla oblongata was most pronouncedly affected. The reticular formation should be among the systems other than motor neurons that may be involved in this type of familial ALS.

UR - http://www.scopus.com/inward/record.url?scp=0026592469&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026592469&partnerID=8YFLogxK

M3 - Article

C2 - 1312404

AN - SCOPUS:0026592469

VL - 11

SP - 41

EP - 44

JO - Clinical Neuropathology

JF - Clinical Neuropathology

SN - 0722-5091

IS - 1

ER -