Involvement of hippocampus in Creutzfeldt-Jakob disease

Hidehiro Mizusawa, Asao Hirano, Josefina F. Llena

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The hippocampus is generally believed to be only rarely affected in Creutzfeldt-Jakob disease. In a systematic study of the hippocampus in 6 cases of Creutzfeldt-Jakob disease, the stratum moleculare-lacunosum showed a definite spongiform change with gliosis in 5 cases. The stratum radiatum et pyramidale showed spongiform change in 3 of the 5 cases. The subiculum, presubiculum, parasubiculum and entorhinal cortex were involved in all the cases. These results suggest that involvement of the hippocampus may not be uncommon in Creutzfeldt-Jakob disease. The stratum moleculare-lacunosum seems to be the site preferentially affected. This pathology may contribute to progression of dementia in Creutzfeldt-Jakob disease.

Original languageEnglish (US)
Pages (from-to)13-26
Number of pages14
JournalJournal of the Neurological Sciences
Issue number1-3
StatePublished - Dec 1987


  • Creutzfeldt-Jakob disease
  • Hippocampus
  • Stratum moleculare-lacunosum

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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