Involvement of hippocampus in Creutzfeldt-Jakob disease

Hidehiro Mizusawa; Asao Hirano; Josefina F. Llena

doi:10.1016/0022-510X(87)90003-7

Involvement of hippocampus in Creutzfeldt-Jakob disease

Hidehiro Mizusawa, Asao Hirano, Josefina F. Llena

Pathology

Research output: Contribution to journal › Article

10 Scopus citations

Abstract

The hippocampus is generally believed to be only rarely affected in Creutzfeldt-Jakob disease. In a systematic study of the hippocampus in 6 cases of Creutzfeldt-Jakob disease, the stratum moleculare-lacunosum showed a definite spongiform change with gliosis in 5 cases. The stratum radiatum et pyramidale showed spongiform change in 3 of the 5 cases. The subiculum, presubiculum, parasubiculum and entorhinal cortex were involved in all the cases. These results suggest that involvement of the hippocampus may not be uncommon in Creutzfeldt-Jakob disease. The stratum moleculare-lacunosum seems to be the site preferentially affected. This pathology may contribute to progression of dementia in Creutzfeldt-Jakob disease.

Original language	English (US)
Pages (from-to)	13-26
Number of pages	14
Journal	Journal of the Neurological Sciences
Volume	82
Issue number	1-3
DOIs	https://doi.org/10.1016/0022-510X(87)90003-7
Publication status	Published - Dec 1987

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Keywords

Creutzfeldt-Jakob disease
Hippocampus
Stratum moleculare-lacunosum

ASJC Scopus subject areas

Neurology
Clinical Neurology

Cite this

Mizusawa, H., Hirano, A., & Llena, J. F. (1987). Involvement of hippocampus in Creutzfeldt-Jakob disease. Journal of the Neurological Sciences, 82(1-3), 13-26. https://doi.org/10.1016/0022-510X(87)90003-7

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10.1016/0022-510X(87)90003-7