Abstract
The hippocampus is generally believed to be only rarely affected in Creutzfeldt-Jakob disease. In a systematic study of the hippocampus in 6 cases of Creutzfeldt-Jakob disease, the stratum moleculare-lacunosum showed a definite spongiform change with gliosis in 5 cases. The stratum radiatum et pyramidale showed spongiform change in 3 of the 5 cases. The subiculum, presubiculum, parasubiculum and entorhinal cortex were involved in all the cases. These results suggest that involvement of the hippocampus may not be uncommon in Creutzfeldt-Jakob disease. The stratum moleculare-lacunosum seems to be the site preferentially affected. This pathology may contribute to progression of dementia in Creutzfeldt-Jakob disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 13-26 |
| Number of pages | 14 |
| Journal | Journal of the Neurological Sciences |
| Volume | 82 |
| Issue number | 1-3 |
| DOIs | |
| State | Published - Dec 1987 |
Keywords
- Creutzfeldt-Jakob disease
- Hippocampus
- Stratum moleculare-lacunosum
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
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Cite this
Mizusawa, H., Hirano, A., & Llena, J. F. (1987). Involvement of hippocampus in Creutzfeldt-Jakob disease. Journal of the Neurological Sciences, 82(1-3), 13-26. https://doi.org/10.1016/0022-510X(87)90003-7