Involvement of hippocampus in Creutzfeldt-Jakob disease

Hidehiro Mizusawa; Asao Hirano; Josefina F. Llena

doi:10.1016/0022-510X(87)90003-7

Involvement of hippocampus in Creutzfeldt-Jakob disease

Hidehiro Mizusawa, Asao Hirano, Josefina F. Llena

Pathology

Research output: Contribution to journal › Article › peer-review

10 Scopus citations

Abstract

The hippocampus is generally believed to be only rarely affected in Creutzfeldt-Jakob disease. In a systematic study of the hippocampus in 6 cases of Creutzfeldt-Jakob disease, the stratum moleculare-lacunosum showed a definite spongiform change with gliosis in 5 cases. The stratum radiatum et pyramidale showed spongiform change in 3 of the 5 cases. The subiculum, presubiculum, parasubiculum and entorhinal cortex were involved in all the cases. These results suggest that involvement of the hippocampus may not be uncommon in Creutzfeldt-Jakob disease. The stratum moleculare-lacunosum seems to be the site preferentially affected. This pathology may contribute to progression of dementia in Creutzfeldt-Jakob disease.

Original language	English (US)
Pages (from-to)	13-26
Number of pages	14
Journal	Journal of the Neurological Sciences
Volume	82
Issue number	1-3
DOIs	https://doi.org/10.1016/0022-510X(87)90003-7
State	Published - Dec 1987

Keywords

Creutzfeldt-Jakob disease
Hippocampus
Stratum moleculare-lacunosum

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.1016/0022-510X(87)90003-7

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title = "Involvement of hippocampus in Creutzfeldt-Jakob disease",

abstract = "The hippocampus is generally believed to be only rarely affected in Creutzfeldt-Jakob disease. In a systematic study of the hippocampus in 6 cases of Creutzfeldt-Jakob disease, the stratum moleculare-lacunosum showed a definite spongiform change with gliosis in 5 cases. The stratum radiatum et pyramidale showed spongiform change in 3 of the 5 cases. The subiculum, presubiculum, parasubiculum and entorhinal cortex were involved in all the cases. These results suggest that involvement of the hippocampus may not be uncommon in Creutzfeldt-Jakob disease. The stratum moleculare-lacunosum seems to be the site preferentially affected. This pathology may contribute to progression of dementia in Creutzfeldt-Jakob disease.",

keywords = "Creutzfeldt-Jakob disease, Hippocampus, Stratum moleculare-lacunosum",

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AU - Hirano, Asao

AU - Llena, Josefina F.

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N2 - The hippocampus is generally believed to be only rarely affected in Creutzfeldt-Jakob disease. In a systematic study of the hippocampus in 6 cases of Creutzfeldt-Jakob disease, the stratum moleculare-lacunosum showed a definite spongiform change with gliosis in 5 cases. The stratum radiatum et pyramidale showed spongiform change in 3 of the 5 cases. The subiculum, presubiculum, parasubiculum and entorhinal cortex were involved in all the cases. These results suggest that involvement of the hippocampus may not be uncommon in Creutzfeldt-Jakob disease. The stratum moleculare-lacunosum seems to be the site preferentially affected. This pathology may contribute to progression of dementia in Creutzfeldt-Jakob disease.

AB - The hippocampus is generally believed to be only rarely affected in Creutzfeldt-Jakob disease. In a systematic study of the hippocampus in 6 cases of Creutzfeldt-Jakob disease, the stratum moleculare-lacunosum showed a definite spongiform change with gliosis in 5 cases. The stratum radiatum et pyramidale showed spongiform change in 3 of the 5 cases. The subiculum, presubiculum, parasubiculum and entorhinal cortex were involved in all the cases. These results suggest that involvement of the hippocampus may not be uncommon in Creutzfeldt-Jakob disease. The stratum moleculare-lacunosum seems to be the site preferentially affected. This pathology may contribute to progression of dementia in Creutzfeldt-Jakob disease.

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