Involvement of cellular proteins in Junin arenavirus entry

M. Guadalupe Martinez; M. Belen Forlenza; Nélida A. Candurra

doi:10.1002/biot.200800357

Involvement of cellular proteins in Junin arenavirus entry

M. Guadalupe Martinez, M. Belen Forlenza, Nélida A. Candurra

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

Junin arenavirus (JUNV) entry is dependent on clathrin-mediated pathways and it relies on the integrity of the actin cytoskeleton as well as the dynamics of microtubules. To determine the method of entry used by this human pathogen, we have demonstrated that in Vero cells JUNV is trafficked via the cellular dynamin 2 (dyn2) endocytic pathway and it is dependent on the Eps15 GTPase. In addition, we have shown that the virus travels through Rab5-mediated early and Rab7-mediated late endosomes in its pH-dependent entry. Altogether, this study gives further inside into the endocytic pathway utilized by the arenavirus JUNV.

Original language	English (US)
Pages (from-to)	866-870
Number of pages	5
Journal	Biotechnology Journal
Volume	4
Issue number	6
DOIs	https://doi.org/10.1002/biot.200800357
State	Published - 2009
Externally published	Yes

Keywords

Arenavirus
Endocytosis
Junin virus

ASJC Scopus subject areas

Applied Microbiology and Biotechnology
Molecular Medicine

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10.1002/biot.200800357

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title = "Involvement of cellular proteins in Junin arenavirus entry",

abstract = "Junin arenavirus (JUNV) entry is dependent on clathrin-mediated pathways and it relies on the integrity of the actin cytoskeleton as well as the dynamics of microtubules. To determine the method of entry used by this human pathogen, we have demonstrated that in Vero cells JUNV is trafficked via the cellular dynamin 2 (dyn2) endocytic pathway and it is dependent on the Eps15 GTPase. In addition, we have shown that the virus travels through Rab5-mediated early and Rab7-mediated late endosomes in its pH-dependent entry. Altogether, this study gives further inside into the endocytic pathway utilized by the arenavirus JUNV.",

keywords = "Arenavirus, Endocytosis, Junin virus",

author = "Martinez, {M. Guadalupe} and Forlenza, {M. Belen} and Candurra, {N{\'e}lida A.}",

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doi = "10.1002/biot.200800357",

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T1 - Involvement of cellular proteins in Junin arenavirus entry

AU - Martinez, M. Guadalupe

AU - Forlenza, M. Belen

AU - Candurra, Nélida A.

PY - 2009

Y1 - 2009

N2 - Junin arenavirus (JUNV) entry is dependent on clathrin-mediated pathways and it relies on the integrity of the actin cytoskeleton as well as the dynamics of microtubules. To determine the method of entry used by this human pathogen, we have demonstrated that in Vero cells JUNV is trafficked via the cellular dynamin 2 (dyn2) endocytic pathway and it is dependent on the Eps15 GTPase. In addition, we have shown that the virus travels through Rab5-mediated early and Rab7-mediated late endosomes in its pH-dependent entry. Altogether, this study gives further inside into the endocytic pathway utilized by the arenavirus JUNV.

AB - Junin arenavirus (JUNV) entry is dependent on clathrin-mediated pathways and it relies on the integrity of the actin cytoskeleton as well as the dynamics of microtubules. To determine the method of entry used by this human pathogen, we have demonstrated that in Vero cells JUNV is trafficked via the cellular dynamin 2 (dyn2) endocytic pathway and it is dependent on the Eps15 GTPase. In addition, we have shown that the virus travels through Rab5-mediated early and Rab7-mediated late endosomes in its pH-dependent entry. Altogether, this study gives further inside into the endocytic pathway utilized by the arenavirus JUNV.

KW - Arenavirus

KW - Endocytosis

KW - Junin virus

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Involvement of cellular proteins in Junin arenavirus entry

Abstract

Keywords

ASJC Scopus subject areas

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