Involvement of canine oral papillomavirus in generalized oral and cutaneous verrucosis in Chinese Shar Pei dog

J. P. Sundberg, E. K. Smith, A. J. Herron, A. B. Jenson, Robert D. Burk, M. Van Ranst

Research output: Contribution to journalArticle

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Abstract

Severe papillomatosis developed in the oral cavity and spread throughout the haired skin of the trunk and limbs of an 8-month-old female Chinese Shar Pei dog. The dog had received corticosteroids prior to referral, which was associated with the onset of demodecosis and papillomatosis. Papillomavirus structural antigens were detected in biopsies by immunohistochemistry using a panel of monoclonal and polyclonal antibodies. An 8.2-kilobase papillomavirus-specific DNA molecule was detected in the cutaneous lesions by high stringency Southern blot hybridization using a cloned canine oral papillomavirus DNA probe. Restriction enzyme analysis revealed that the virus in the cutaneous lesions was identical to the canine orla papillomavirus. Discontinuation of the steroids combined with the use of a mitocide, antibiotics, and an autogenous vaccine resolved the demodecosis and papillomatosis. This case report suggests that corticosteroid-induced immunosuppression can expand the tissue tropism of papillomaviruses.

Original languageEnglish (US)
Pages (from-to)183-187
Number of pages5
JournalVeterinary Pathology
Volume31
Issue number2
StatePublished - 1994

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Lambdapapillomavirus
Canine oral papillomavirus
Papillomaviridae
Papilloma
papilloma
mouth
Dogs
demodicosis
Skin
dogs
Adrenal Cortex Hormones
Autovaccines
skin lesions
adrenal cortex hormones
Restriction Mapping
Tropism
DNA Probes
tissue tropism
Southern Blotting
Immunosuppression

Keywords

  • immunosuppression
  • oral cavity
  • papillomavirus
  • skin
  • steroids

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Sundberg, J. P., Smith, E. K., Herron, A. J., Jenson, A. B., Burk, R. D., & Van Ranst, M. (1994). Involvement of canine oral papillomavirus in generalized oral and cutaneous verrucosis in Chinese Shar Pei dog. Veterinary Pathology, 31(2), 183-187.

Involvement of canine oral papillomavirus in generalized oral and cutaneous verrucosis in Chinese Shar Pei dog. / Sundberg, J. P.; Smith, E. K.; Herron, A. J.; Jenson, A. B.; Burk, Robert D.; Van Ranst, M.

In: Veterinary Pathology, Vol. 31, No. 2, 1994, p. 183-187.

Research output: Contribution to journalArticle

Sundberg, JP, Smith, EK, Herron, AJ, Jenson, AB, Burk, RD & Van Ranst, M 1994, 'Involvement of canine oral papillomavirus in generalized oral and cutaneous verrucosis in Chinese Shar Pei dog', Veterinary Pathology, vol. 31, no. 2, pp. 183-187.
Sundberg, J. P. ; Smith, E. K. ; Herron, A. J. ; Jenson, A. B. ; Burk, Robert D. ; Van Ranst, M. / Involvement of canine oral papillomavirus in generalized oral and cutaneous verrucosis in Chinese Shar Pei dog. In: Veterinary Pathology. 1994 ; Vol. 31, No. 2. pp. 183-187.
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