InVivo thermal ablation monitoring using ultrasound echo decorrelation imaging

Swetha Subramanian, Steven M. Rudich, Amel Alqadah, Chandra Priya Karunakaran, Marepalli B. Rao, T. Douglas Mast

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Previous work indicated that ultrasound echo decorrelation imaging can track and quantify changes in echo signals to predict thermal damage during invitro radiofrequency ablation (RFA). In the invivo studies reported here, the feasibility of using echo decorrelation imaging as a treatment monitoring tool was assessed. RFA was performed on normal swine liver (N= 5), and ultrasound ablation using image-ablate arrays was performed on rabbit liver implanted with VX2 tumors (N= 2). Echo decorrelation and integrated backscatter were computed from Hilbert transformed pulse-echo data acquired during RFA and ultrasound ablation treatments. Receiver operating characteristic (ROC) curves were employed to assess the ability of echo decorrelation imaging and integrated backscatter to predict ablation. Area under the ROC curves (AUROC) was determined for RFA and ultrasound ablation using echo decorrelation imaging. Ablation was predicted more accurately using echo decorrelation imaging (AUROC= 0.832 and 0.776 for RFA and ultrasound ablation, respectively) than using integrated backscatter (AUROC= 0.734 and 0.494).

Original languageEnglish (US)
Pages (from-to)102-114
Number of pages13
JournalUltrasound in Medicine and Biology
Volume40
Issue number1
DOIs
StatePublished - Jan 2014
Externally publishedYes

Fingerprint

ROC Curve
ablation
echoes
Hot Temperature
Area Under Curve
Liver
Feasibility Studies
Swine
curves
liver
Rabbits
receivers
swine
Neoplasms
rabbits
tumors
damage

Keywords

  • Bulk ultrasound ablation
  • Echo decorrelation imaging
  • Radiofrequency ablation
  • Therapy monitoring

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics

Cite this

InVivo thermal ablation monitoring using ultrasound echo decorrelation imaging. / Subramanian, Swetha; Rudich, Steven M.; Alqadah, Amel; Karunakaran, Chandra Priya; Rao, Marepalli B.; Mast, T. Douglas.

In: Ultrasound in Medicine and Biology, Vol. 40, No. 1, 01.2014, p. 102-114.

Research output: Contribution to journalArticle

Subramanian, Swetha ; Rudich, Steven M. ; Alqadah, Amel ; Karunakaran, Chandra Priya ; Rao, Marepalli B. ; Mast, T. Douglas. / InVivo thermal ablation monitoring using ultrasound echo decorrelation imaging. In: Ultrasound in Medicine and Biology. 2014 ; Vol. 40, No. 1. pp. 102-114.
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