Investigating the effects of metabolic dysregulation on hair follicles: A comparison of HIV-infected women with and without central lipohypertrophy

Paradi Mirmirani, Toby Maurer, Mardge Cohen, Gypsymber D'Souza, Roksana Karim, Michael Plankey, Esther Robison, Anjali Sharma, Phyllis C. Tien, Nancy A. Hessol

Research output: Contribution to journalArticle

Abstract

Background: Normal lipid metabolism and functioning of the peroxisome proliferatoractivated receptor gamma (PPAR-gamma) in the sebaceous gland is critical to maintaining a normal hair follicle. Human immunodeficiency virus (HIV) infection affects lipid metabolism; some have hypothesized a link between PPAR-gamma function and lipodystrophy in HIV infection. Our objective was to determine whether lipodystrophy is associated with altered hair characteristics in HIV-infected women from the Women's Interagency HIV Study. Methods: Hair characteristics and scalp inflammation were assessed by an intervieweradministered questionnaire. Central lipohypertrophy and peripheral lipoatrophy were defined by self-report of moderate to severe fat gain in central body sites and fat loss in peripheral body sites, respectively confirmed by clinical examination. Additional covariates considered in the analyses included demographics, behavioral characteristics, medical history, and HIV-related factors. Results: There were 1037 women with data on all study variables; 76 women reported central lipohypertrophy, while only four women reported lipoatrophy. Women with central lipohypertrophy were more likely to be older, had a self-reported history of injection drug use, statin medication use, diabetes, elevated cholesterol, and have self-reported less hair and shorter eyelashes. After adjustment for age, central lipohypertrophy was associated with shorter eyelashes (OR 2.3; 95% CI 1.4-3.8). Conclusions: Central lipohypertrophy was not associated with change in scalp hair texture or scalp inflammation in this cohort. Rather, we found an association between central lipohypertrophy and shorter eyelash length. This finding may be explained by an influence of prostaglandin E2 mediators on eyelash follicles.

Original languageEnglish (US)
Pages (from-to)e443-e448
JournalInternational Journal of Dermatology
Volume53
Issue number10
StatePublished - 2014
Externally publishedYes

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Hair Follicle
Eyelashes
HIV
Hair
Scalp
Lipodystrophy
Peroxisomes
Virus Diseases
Lipid Metabolism
Fats
Inflammation
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Sebaceous Glands
Hypercholesterolemia
Dinoprostone
Self Report
Demography
Injections
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Dermatology

Cite this

Mirmirani, P., Maurer, T., Cohen, M., D'Souza, G., Karim, R., Plankey, M., ... Hessol, N. A. (2014). Investigating the effects of metabolic dysregulation on hair follicles: A comparison of HIV-infected women with and without central lipohypertrophy. International Journal of Dermatology, 53(10), e443-e448.

Investigating the effects of metabolic dysregulation on hair follicles : A comparison of HIV-infected women with and without central lipohypertrophy. / Mirmirani, Paradi; Maurer, Toby; Cohen, Mardge; D'Souza, Gypsymber; Karim, Roksana; Plankey, Michael; Robison, Esther; Sharma, Anjali; Tien, Phyllis C.; Hessol, Nancy A.

In: International Journal of Dermatology, Vol. 53, No. 10, 2014, p. e443-e448.

Research output: Contribution to journalArticle

Mirmirani, P, Maurer, T, Cohen, M, D'Souza, G, Karim, R, Plankey, M, Robison, E, Sharma, A, Tien, PC & Hessol, NA 2014, 'Investigating the effects of metabolic dysregulation on hair follicles: A comparison of HIV-infected women with and without central lipohypertrophy', International Journal of Dermatology, vol. 53, no. 10, pp. e443-e448.
Mirmirani, Paradi ; Maurer, Toby ; Cohen, Mardge ; D'Souza, Gypsymber ; Karim, Roksana ; Plankey, Michael ; Robison, Esther ; Sharma, Anjali ; Tien, Phyllis C. ; Hessol, Nancy A. / Investigating the effects of metabolic dysregulation on hair follicles : A comparison of HIV-infected women with and without central lipohypertrophy. In: International Journal of Dermatology. 2014 ; Vol. 53, No. 10. pp. e443-e448.
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AU - Maurer, Toby

AU - Cohen, Mardge

AU - D'Souza, Gypsymber

AU - Karim, Roksana

AU - Plankey, Michael

AU - Robison, Esther

AU - Sharma, Anjali

AU - Tien, Phyllis C.

AU - Hessol, Nancy A.

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N2 - Background: Normal lipid metabolism and functioning of the peroxisome proliferatoractivated receptor gamma (PPAR-gamma) in the sebaceous gland is critical to maintaining a normal hair follicle. Human immunodeficiency virus (HIV) infection affects lipid metabolism; some have hypothesized a link between PPAR-gamma function and lipodystrophy in HIV infection. Our objective was to determine whether lipodystrophy is associated with altered hair characteristics in HIV-infected women from the Women's Interagency HIV Study. Methods: Hair characteristics and scalp inflammation were assessed by an intervieweradministered questionnaire. Central lipohypertrophy and peripheral lipoatrophy were defined by self-report of moderate to severe fat gain in central body sites and fat loss in peripheral body sites, respectively confirmed by clinical examination. Additional covariates considered in the analyses included demographics, behavioral characteristics, medical history, and HIV-related factors. Results: There were 1037 women with data on all study variables; 76 women reported central lipohypertrophy, while only four women reported lipoatrophy. Women with central lipohypertrophy were more likely to be older, had a self-reported history of injection drug use, statin medication use, diabetes, elevated cholesterol, and have self-reported less hair and shorter eyelashes. After adjustment for age, central lipohypertrophy was associated with shorter eyelashes (OR 2.3; 95% CI 1.4-3.8). Conclusions: Central lipohypertrophy was not associated with change in scalp hair texture or scalp inflammation in this cohort. Rather, we found an association between central lipohypertrophy and shorter eyelash length. This finding may be explained by an influence of prostaglandin E2 mediators on eyelash follicles.

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