TY - JOUR
T1 - Investigating co-evolution of functionally associated phosphosites in human
AU - Liu, Zhi
AU - Zheng, Guangyong
AU - Dong, Xiao
AU - Wang, Zhen
AU - Ying, Beili
AU - Zhong, Yang
AU - Li, Yixue
N1 - Publisher Copyright:
© 2014, Springer-Verlag Berlin Heidelberg.
PY - 2014
Y1 - 2014
N2 - Phosphorylation is essential for protein function and signal transduction in eukaryotic cells. With the rapid development of mass spectrometry technology, a large number of phosphosites are identified. However, high-throughput methods of functional characterization for phosphosites are still scarce. In this study, we inspected if the co-evolution property can be used as an indicator to explore function of phosphosites through investigating co-evolutionary relationship between functionally associated phosphosites in human. In practice, the evolution attributes of phosphosites were represented with phylogenetic profiles, and then co-evolutionary correlations of functionally associated phosphosites were detected on three levels: (1) phosphosites within one protein; (2) phosphosites in different proteins participating in the same signal transduction pathways, and (3) general phosphosites. Results of the detection show that co-evolution is a general property of functionally associated phosphosites. This finding suggests to some degree that it is feasible to use the co-evolution property in exploring the function of phosphosites and investigating the functional association between them.
AB - Phosphorylation is essential for protein function and signal transduction in eukaryotic cells. With the rapid development of mass spectrometry technology, a large number of phosphosites are identified. However, high-throughput methods of functional characterization for phosphosites are still scarce. In this study, we inspected if the co-evolution property can be used as an indicator to explore function of phosphosites through investigating co-evolutionary relationship between functionally associated phosphosites in human. In practice, the evolution attributes of phosphosites were represented with phylogenetic profiles, and then co-evolutionary correlations of functionally associated phosphosites were detected on three levels: (1) phosphosites within one protein; (2) phosphosites in different proteins participating in the same signal transduction pathways, and (3) general phosphosites. Results of the detection show that co-evolution is a general property of functionally associated phosphosites. This finding suggests to some degree that it is feasible to use the co-evolution property in exploring the function of phosphosites and investigating the functional association between them.
KW - Co-evolution
KW - Functional association
KW - Phosphorylation site
KW - Phylogenetic profile
KW - Post-translational modification
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U2 - 10.1007/s00438-014-0881-x
DO - 10.1007/s00438-014-0881-x
M3 - Article
C2 - 25005854
AN - SCOPUS:84922479976
SN - 1617-4615
SP - 1217
EP - 1223
JO - Molecular Genetics and Genomics
JF - Molecular Genetics and Genomics
ER -