TY - JOUR
T1 - Inverse association of physical fitness with plasma fibrinogen level in children
T2 - The Columbia University BioMarkers Study
AU - Isasi, Carmen R.
AU - Starc, Thomas J.
AU - Tracy, Russell P.
AU - Deckelbaum, Richard
AU - Berglund, Lars
AU - Shea, Steven
N1 - Funding Information:
Supported in part by grants from the US Department of Education (HO24530014), the Florida Department of Education (011–92000–60001), Lawton and Rhea Chiles Center for Healthy Mothers and Babies, and the University of Florida Office of Research, Technology, and Graduate Education.
PY - 2000/8/1
Y1 - 2000/8/1
N2 - Plasma fibrinogen has emerged as a risk factor for cardiovascular disease in adults, but relatively little is known about the correlates of plasma fibrinogen level in childhood. In the Columbia University BioMarkers Study (1994-1998), the authors evaluated the association between physical fitness and plasma fibrinogen level in 193 children 4-25 years old; 68% were Hispanic and 46% male. Fitness level assessed by treadmill testing was inversely associated with plasma fibrinogen (r = -0.24, p < 0.001). Plasma fibrinogen levels showed a graded inverse relation with tertiles of fitness assessed by treadmill (p < 0.001). In multivariate analyses, after adjustment for age, sex, race/ethnicity, body mass index, and presence of the A allele in the -455 position of the β-fibrinogen promoter gene, the fitness level remained inversely associated with plasma fibrinogen level (β = -1.3, 95% confidence interval (CI):-2.3, -0.34). Resting heart rate was also correlated with plasma fibrinogen level (r = 0.18, p < 0.05). Fibrinogen levels (mg/dl) increased over tertiles of resting heart rate (p = 0.002) and were significantly associated with resting heart rate in multivariate analysis (β = 0.82, 95% CI: 0.17, 1.5). These findings indicate that plasma fibrinogen is inversely associated with physical fitness in children independent of body mass index.
AB - Plasma fibrinogen has emerged as a risk factor for cardiovascular disease in adults, but relatively little is known about the correlates of plasma fibrinogen level in childhood. In the Columbia University BioMarkers Study (1994-1998), the authors evaluated the association between physical fitness and plasma fibrinogen level in 193 children 4-25 years old; 68% were Hispanic and 46% male. Fitness level assessed by treadmill testing was inversely associated with plasma fibrinogen (r = -0.24, p < 0.001). Plasma fibrinogen levels showed a graded inverse relation with tertiles of fitness assessed by treadmill (p < 0.001). In multivariate analyses, after adjustment for age, sex, race/ethnicity, body mass index, and presence of the A allele in the -455 position of the β-fibrinogen promoter gene, the fitness level remained inversely associated with plasma fibrinogen level (β = -1.3, 95% confidence interval (CI):-2.3, -0.34). Resting heart rate was also correlated with plasma fibrinogen level (r = 0.18, p < 0.05). Fibrinogen levels (mg/dl) increased over tertiles of resting heart rate (p = 0.002) and were significantly associated with resting heart rate in multivariate analysis (β = 0.82, 95% CI: 0.17, 1.5). These findings indicate that plasma fibrinogen is inversely associated with physical fitness in children independent of body mass index.
KW - Body mass index
KW - Cardiovascular diseases
KW - Fibrinogen
KW - Risk factors
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U2 - 10.1093/aje/152.3.212
DO - 10.1093/aje/152.3.212
M3 - Article
C2 - 10933267
AN - SCOPUS:0034255066
SN - 0002-9262
VL - 152
SP - 212
EP - 218
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
IS - 3
ER -