TY - JOUR
T1 - Invasive Infections Due to Candida krusei
T2 - Report of Ten Cases of Fungemia that Include Three Cases of Endophthalmitis
AU - McQuillen, Daniel P.
AU - Zingman, Barry S.
AU - Meunier, Françoise
AU - Levitz, Stuart M.
N1 - Funding Information:
Received 16 April 1991; revised 18 July 1991. • Present affiliation: Montefiore Medical Center. Bronx, New York. t Present affiliation: Belgian National Fund for Scientific Research and Data Center of the European Organization for Research and Treatment of Cancer, Brussels. Belgium. Reprints or correspondence: Dr: Stuart M. Levitz. Section of Infectious Diseases, The University Hospital. Room E 540, 88 East Newton Street. Boston, Massachusetts 02118.
PY - 1992/2
Y1 - 1992/2
N2 - Candida krusei has become an increasingly important invasive pathogen, particularly in immunocompromised patients. Previous experimental and clinical experience suggest that C. krusei has a low propensity for hematogenously infecting the eye. We report 10 cases of fungemia due to C. krusei at our institutions, including three cases of endophthalmitis due to C. krusei. Fungemia was associated with nodular skin lesions in all seven patients with neutropenia and occurred despite administration of antifungal prophylaxis or empirical therapy. None of the patients apparently died as a direct result of C. krusei fungemia. Treatment with amphotericin B resulted in resolution of endophthalmitis, although one patient required vitrectomy. Early institution of aggressive therapy with amphotericin B may alter the course and improve the prognosis of C. krusei infection, particularly in immunocompromised patients.
AB - Candida krusei has become an increasingly important invasive pathogen, particularly in immunocompromised patients. Previous experimental and clinical experience suggest that C. krusei has a low propensity for hematogenously infecting the eye. We report 10 cases of fungemia due to C. krusei at our institutions, including three cases of endophthalmitis due to C. krusei. Fungemia was associated with nodular skin lesions in all seven patients with neutropenia and occurred despite administration of antifungal prophylaxis or empirical therapy. None of the patients apparently died as a direct result of C. krusei fungemia. Treatment with amphotericin B resulted in resolution of endophthalmitis, although one patient required vitrectomy. Early institution of aggressive therapy with amphotericin B may alter the course and improve the prognosis of C. krusei infection, particularly in immunocompromised patients.
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U2 - 10.1093/clinids/14.2.472
DO - 10.1093/clinids/14.2.472
M3 - Article
C2 - 1554833
AN - SCOPUS:0026515793
SN - 1058-4838
VL - 14
SP - 472
EP - 478
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
IS - 2
ER -
