Invasive Infections Due to Candida krusei: Report of Ten Cases of Fungemia that Include Three Cases of Endophthalmitis

Daniel P. McQuillen, Barry S. Zingman, Françoise Meunier, Stuart M. Levitz

Research output: Contribution to journalArticle

69 Scopus citations

Abstract

Candida krusei has become an increasingly important invasive pathogen, particularly in immunocompromised patients. Previous experimental and clinical experience suggest that C. krusei has a low propensity for hematogenously infecting the eye. We report 10 cases of fungemia due to C. krusei at our institutions, including three cases of endophthalmitis due to C. krusei. Fungemia was associated with nodular skin lesions in all seven patients with neutropenia and occurred despite administration of antifungal prophylaxis or empirical therapy. None of the patients apparently died as a direct result of C. krusei fungemia. Treatment with amphotericin B resulted in resolution of endophthalmitis, although one patient required vitrectomy. Early institution of aggressive therapy with amphotericin B may alter the course and improve the prognosis of C. krusei infection, particularly in immunocompromised patients.

Original languageEnglish (US)
Pages (from-to)472-478
Number of pages7
JournalClinical Infectious Diseases
Volume14
Issue number2
DOIs
StatePublished - Feb 1992

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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