Intrinsic and extrinsic mechanisms of dendritic morphogenesis

Xintong Dong, Kang Shen, Hannes E. Buelow

Research output: Contribution to journalArticle

51 Citations (Scopus)

Abstract

The complex, branched morphology of dendrites is a cardinal feature of neurons and has been used as a criterion for cell type identification since the beginning of neurobiology. Regulated dendritic outgrowth and branching during development form the basis of receptive fields for neurons and are essential for the wiring of the nervous system. The cellular and molecular mechanisms of dendritic morphogenesis have been an intensely studied area. In this review, we summarize the major experimental systems that have contributed to our understandings of dendritic development as well as the intrinsic and extrinsic mechanisms that instruct the neurons to form cell type-specific dendritic arbors.

Original languageEnglish (US)
Pages (from-to)271-300
Number of pages30
JournalAnnual Review of Physiology
Volume77
DOIs
StatePublished - Feb 1 2015

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Morphogenesis
Neurons
Neurobiology
Dendrites
Dendritic Cells
Nervous System

Keywords

  • Branching
  • Dendrite
  • Development
  • Neuron
  • Receptor-ligand interaction
  • Self-avoidance
  • Transcriptional regulation

ASJC Scopus subject areas

  • Physiology

Cite this

Intrinsic and extrinsic mechanisms of dendritic morphogenesis. / Dong, Xintong; Shen, Kang; Buelow, Hannes E.

In: Annual Review of Physiology, Vol. 77, 01.02.2015, p. 271-300.

Research output: Contribution to journalArticle

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