Intravital imaging of metastatic behavior through a mammary imaging window

Dmitriy Kedrin, Bojana Gligorijevic, Jeffrey Wyckoff, Vladislav V. Verkhusha, John Condeelis, Jeffrey E. Segall, Jacco van Rheenen

Research output: Contribution to journalArticle

262 Scopus citations

Abstract

We report a technique to evaluate the same tumor microenvironment over multiple intravital imaging sessions in living mice. We optically marked individual tumor cells expressing photoswitchable proteins in an orthotopic mammary carcinoma and followed them for extended periods through a mammary imaging window. We found that two distinct microenvironments in the same orthotopic mammary tumor affected differently the invasion and intravasation of tumor cells.

Original languageEnglish (US)
Pages (from-to)1019-1021
Number of pages3
JournalNature Methods
Volume5
Issue number12
DOIs
StatePublished - Nov 7 2008

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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