Intraventricular Pressure Gradients in Left Ventricular Aneurysms Determined by Color M-Mode Doppler Method: An Animal Study

Junko Asada-Kamiguchi, Michael Jones, Neil L. Greenberg, Zoran B. Popovic, Hiroyuki Tsujino, Arthur D. Zetts, Jian Xin Qin, Mario J. Garcia, James D. Thomas, Takahiro Shiota

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Background: Left ventricular aneurysm (LVA) may affect diastolic intraventricular blood flow. Color M-mode (CMM) Doppler flow propagation patterns are abnormal in the presence of apical aneurysms. The aim of this study was to validate the accuracy of CMM echocardiography for assessing the existence and size of LVA and to determine the intraventricular pressure gradient in LVA. Methods: CMM of the transmitral inflow in early diastole was obtained from the apical 4-chamber view in 19 sheep. The presence of the break point where the velocity decreased abruptly in the mitral inflow (point D) was determined and the distance between the apex and point D was measured. The intraventricular pressure difference between the base and the apex was measured by a catheter while it was calculated using CMM with the Euler equation. Results: The presence of the break point D showed 84% sensitivity and 100% specificity for determining the existence of an LVA. Distance between the apex and point D correlated well with scar size. Catheter- and CMM-derived intraventricular pressure difference correlated and agreed well (y = 1.0 × -0.2, r = 0.94). Conclusions: The point of abrupt decrease in propagation velocity of the CMM recording indicated the presence and size of LVA. Intraventricular pressure gradients were determined noninvasively by CMM echocardiography with reasonable accuracy.

Original languageEnglish (US)
Pages (from-to)1112-1118
Number of pages7
JournalJournal of the American Society of Echocardiography
Issue number9
Publication statusPublished - Sep 1 2006
Externally publishedYes


ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

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