TY - JOUR
T1 - Intravenous PEG-asparaginase during remission induction in children and adolescents with newly diagnosed acute lymphoblastic leukemia
AU - Silverman, Lewis B.
AU - Supko, Jeffrey G.
AU - Stevenson, Kristen E.
AU - Woodward, Christina
AU - Vrooman, Lynda M.
AU - Neuberg, Donna S.
AU - Asselin, Barbara L.
AU - Athale, Uma H.
AU - Clavell, Luis
AU - Cole, Peter D.
AU - Kelly, Kara M.
AU - Laverdière, Caroline
AU - Michon, Bruno
AU - Schorin, Marshall
AU - Schwartz, Cindy L.
AU - O'Brien, Jane E.
AU - Cohen, Harvey J.
AU - Sallan, Stephen E.
PY - 2010/2/18
Y1 - 2010/2/18
N2 - Over the past several decades, L-asparaginase, an important component of therapy for acute lymphoblastic leukemia (ALL), has typically been administered intramuscularly rather than intravenously in North America because of concerns regarding anaphylaxis.We evaluated the feasibility of giving polyethylene glycosylated (PEG)-asparaginase, the polyethylene glycol conjugate of Escherichia coli L-asparaginase, by intravenous infusion in children with ALL. Between 2005 and 2007, 197 patients (age, 1-17 years) were enrolled on Dana-Farber Cancer Institute ALL Consortium Protocol 05-01 and received a single dose of intravenous PEG-asparaginase (2500 IU/m2) over 1 hour during emission induction. Serum asparaginase activity more than 0.1 IU/mL was detected in 95%, 88%, and 7% of patients at 11, 18, and 25 days after dosing, respectively. Toxicities included allergy (1.5%), venous thrombosis (2%), and pancreatitis (4.6%). We conclude that intravenous administration of PEG-asparaginase is tolerable in children with ALL, and potentially therapeutic enzyme activity is maintained for at least 2 weeks after a single dose in most patients. This trial was registered at www.clinicaltrials.gov as #NCT00400946. (Blood. 2010;115:1351-1353)
AB - Over the past several decades, L-asparaginase, an important component of therapy for acute lymphoblastic leukemia (ALL), has typically been administered intramuscularly rather than intravenously in North America because of concerns regarding anaphylaxis.We evaluated the feasibility of giving polyethylene glycosylated (PEG)-asparaginase, the polyethylene glycol conjugate of Escherichia coli L-asparaginase, by intravenous infusion in children with ALL. Between 2005 and 2007, 197 patients (age, 1-17 years) were enrolled on Dana-Farber Cancer Institute ALL Consortium Protocol 05-01 and received a single dose of intravenous PEG-asparaginase (2500 IU/m2) over 1 hour during emission induction. Serum asparaginase activity more than 0.1 IU/mL was detected in 95%, 88%, and 7% of patients at 11, 18, and 25 days after dosing, respectively. Toxicities included allergy (1.5%), venous thrombosis (2%), and pancreatitis (4.6%). We conclude that intravenous administration of PEG-asparaginase is tolerable in children with ALL, and potentially therapeutic enzyme activity is maintained for at least 2 weeks after a single dose in most patients. This trial was registered at www.clinicaltrials.gov as #NCT00400946. (Blood. 2010;115:1351-1353)
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UR - http://www.scopus.com/inward/citedby.url?scp=77949895397&partnerID=8YFLogxK
U2 - 10.1182/blood-2009-09-245951
DO - 10.1182/blood-2009-09-245951
M3 - Article
C2 - 20007809
AN - SCOPUS:77949895397
SN - 0006-4971
VL - 115
SP - 1351
EP - 1353
JO - Blood
JF - Blood
IS - 7
ER -
