Intravenous Gammaglobulin Treatment in HIV-1 Infection

Avi Deener, Ami Mehra, Larry Bernstein, Jenny Shliozberg, Arye Rubinstein

Research output: Contribution to journalReview article

8 Scopus citations

Abstract

The two main indications for the use of intravenous gammaglobulin-antibody replacement therapy and immunomodulation-are pertinent only for a few scenarios in HIV-1 infection. The role of gammaglobulin in the treatment of HIV-1 infection has changed significantly with the introduction of highly active antiretroviral therapy. Antiretroviral drugs have not only controlled the progression of disease but also had far-reaching effects on HIV-1-induced immunologic aberrations. Complete or partial immunologic reconstitution and prevention of immunologic damage have been the hallmarks of success for highly active antiretroviral therapy. This article addresses the use of gammaglobulin before and after the era of effective antiretroviral therapies.

Original languageEnglish (US)
Pages (from-to)851-859
Number of pages9
JournalImmunology and Allergy Clinics of North America
Volume28
Issue number4
DOIs
StatePublished - Nov 1 2008

Keywords

  • AIDS
  • B cells
  • HIV-1
  • Highly active antiretroviral therapy (HAART)
  • Immunodeficiency
  • Opportunistic infections
  • T cells
  • Thrombocytopenia

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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