Intravenous caffeine versus intravenous ketorolac for the management of moderate to severe migraine headache

Alireza Baratloo, Sara Arab Bafarani, Mohammad Mehdi Forouzanfar, Behrooz Hashemi, Benjamin W. Friedman, Ali Abdalvand

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

The aim of this study was to determine if intravenous caffeine is as effective as intravenous ketorolac for the treatment of moderate to severe migraine headaches. Eligible patients randomly received 60 mg caffeine citrate or 60 mg ketorolac infused intravenously. Their pain score were measured at baseline, one hour and two hours after infusion. Therapeutic success was defined as decreasing of at least 3 points on the pain score. In total 110 patients were enrolled (75.5% women). Therapeutic success after 60 min was achieved by 63.6% of patients in the caffeine and 70.1% of patients in the ketorolac group (p = 0.23). After 120 min, 87.3% of the caffeine group and 83.6% of the ketorolac group achieved therapeutic success (p = 0.49). In this multi-center, randomized double blind study, intravenous caffeine was as effective as intravenous ketorolac for first line abortive management of acute migraine.

Original languageEnglish (US)
Pages (from-to)428-432
Number of pages5
JournalBangladesh Journal of Pharmacology
Volume11
Issue number2
DOIs
Publication statusPublished - 2016

    Fingerprint

ASJC Scopus subject areas

  • Pharmacology

Cite this