Intravascular metabolism of normal and mutant mouse immunoglobulin molecules

Roberta R. Pollock, Deborah L. French, Joshua P. Metlay, Barbara K. Birshtein, Matthew D. Scharff

Research output: Contribution to journalArticle

28 Scopus citations

Abstract

The metabolism of IgG immunoglobulins in the body is tightly regulated in order to maintain their intravascular concentration. Different subclasses may have different intravascular half‐lives, and in the mouse, passively administered IgG2b disappears from the circulation more rapidly than IgG2a. We have attempted to localize the sequences in the constant region which are responsible for this difference by examining the intravascular metabolism of mutant immunoglobulins that were generated in tissue culture and have undergone deletions of individual constant region domains or contain different combinations of γ2b and γ2a CH2 and CH3 domains. Our results suggest that the regulation of intravascular metabolism is complex but indicate that sequences in the CH3 domain are important in determining the different intravascular half‐lives of IgG2b and IgG2a antibodies in the mouse.

Original languageEnglish (US)
Pages (from-to)2021-2027
Number of pages7
JournalEuropean Journal of Immunology
Volume20
Issue number9
DOIs
StatePublished - Sep 1990

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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