Intrauterine transmission of hepatitis A virus

Enid Leikin, Andrzej Lysikiewicz, David Garry, Nergesh Tejani

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Background: Hepatitis A is a common, self-limited disease transmitted by fecal-oral contamination. Case: A 23-year-old woman, para 2-0-0-2, developed hepatitis A at 20 weeks' gestation. At 27 weeks, ultrasound revealed polyhydramnios and fetal ascites. Hepatitis A immunoglobulin M antibody in fetal blood obtained by funipuncture confirmed acute hepatitis A infection in the fetus. Polyhydramnios and ascites persisted until 35 weeks, when the fetus developed ultrasound signs of meconium peritonitis, and delivery was accomplished uneventfully. Meconium peritonitis was diagnosed in the neonatal period and treated surgically. Conclusion: To our knowledge, this is the first report of intrauterine transmission of hepatitis A. The disease presented with fetal ascites and was confirmed by positive fetal blood serology.

Original languageEnglish (US)
Pages (from-to)690-691
Number of pages2
JournalObstetrics and Gynecology
Volume88
Issue number4 II SUPPL.
DOIs
StatePublished - Oct 1996
Externally publishedYes

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Hepatitis A virus
Hepatitis A
Ascites
Polyhydramnios
Meconium
Peritonitis
Fetal Blood
Fetus
Serology
Immunoglobulin M
Pregnancy
Antibodies
Infection

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Leikin, E., Lysikiewicz, A., Garry, D., & Tejani, N. (1996). Intrauterine transmission of hepatitis A virus. Obstetrics and Gynecology, 88(4 II SUPPL.), 690-691. https://doi.org/10.1016/0029-7844(96)00259-1

Intrauterine transmission of hepatitis A virus. / Leikin, Enid; Lysikiewicz, Andrzej; Garry, David; Tejani, Nergesh.

In: Obstetrics and Gynecology, Vol. 88, No. 4 II SUPPL., 10.1996, p. 690-691.

Research output: Contribution to journalArticle

Leikin, E, Lysikiewicz, A, Garry, D & Tejani, N 1996, 'Intrauterine transmission of hepatitis A virus', Obstetrics and Gynecology, vol. 88, no. 4 II SUPPL., pp. 690-691. https://doi.org/10.1016/0029-7844(96)00259-1
Leikin E, Lysikiewicz A, Garry D, Tejani N. Intrauterine transmission of hepatitis A virus. Obstetrics and Gynecology. 1996 Oct;88(4 II SUPPL.):690-691. https://doi.org/10.1016/0029-7844(96)00259-1
Leikin, Enid ; Lysikiewicz, Andrzej ; Garry, David ; Tejani, Nergesh. / Intrauterine transmission of hepatitis A virus. In: Obstetrics and Gynecology. 1996 ; Vol. 88, No. 4 II SUPPL. pp. 690-691.
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