Intratissue DNA Methylation Heterogeneity in Aging

Jan Vijg, Xiao Dong, Silvia Gravina

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

DNA methylation is a critical epigenetic marker involved in development, differentiation, and cell fate diversity. Here we discuss the possible role of adaptive and stochastic changes in DNA methylation in aging. We describe recent progress in studying stochastic changes in DNA methylation, most notably alterations at the level of the single cell. We show that fidelity of individual CpG sites is several orders of magnitude lower than the fidelity of DNA sequence integrity. At this high level of instability, age-related methylation changes could well be a cause of the gradual loss of specific cell fate or differentiation status and, therefore contribute to loss of function and increased disease risk at old age. However, the current lack of a complete understanding of the relationship between DNA methylation patterns and gene expression essentially constrains definite conclusions about the impact of DNA methylation changes on the aging process.

Original languageEnglish (US)
Title of host publicationEpigenetics of Aging and Longevity
Subtitle of host publicationTranslational Epigenetics vol 4
PublisherElsevier
Pages201-209
Number of pages9
ISBN (Electronic)9780128110607
ISBN (Print)9780128110836
DOIs
StatePublished - Jan 1 2018

Keywords

  • Aging
  • CpG islands
  • DNA methylation
  • Epigenetic variation
  • Single-cell methylomics

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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