Intrathecal baclofen for management of spastic cerebral palsy: Multicenter trial

Richard Gilmartin, Derek Bruce, Bruce B. Storrs, Rick Abbott, Linda Krach, John Ward, Karen Bloom, William H. Brooks, Dennis L. Johnson, Joseph R. Madsen, John F. McLaughlin, Joseph Nadell

Research output: Contribution to journalArticle

184 Scopus citations

Abstract

Intrathecal baclofen infusion has demonstrated effectiveness in decreasing spasticity of spinal origin. Oral antispasticity medication is minimally effective or not well tolerated in cerebral palsy. This study assessed the effectiveness of intrathecal baclofen in reducing spasticity in cerebral palsy. Candidates were screened by randomized, double-blind, intrathecal injections of baclofen and placebo. Responders were defined as those who experienced an average reduction of 1.0 in the lower extremities on the Ashworth Scale for spasticity. Responders received intrathecal baclofen via the SynchroMed System and were followed for up to 43 months. Fifty-one patients completed screening and 44 entered open-label trials. Lower- extremity spasticity decreased from an average baseline score of 3.64 to 1.90 at 39 months. A decrease in upper-extremity spasticity was evidenced over the same study period. Forty-two patients reported adverse events. Most common reports were hypotonia, seizures (no new onset), somnolence, and nausea or vomiting. Fifty-nine percent of the patients experienced procedural or system-related events. Spasticity in patients with cerebral palsy can be treated effectively by continuous intrathecal baclofen. Adverse events, although common, were manageable.

Original languageEnglish (US)
Pages (from-to)71-77
Number of pages7
JournalJournal of Child Neurology
Volume15
Issue number2
DOIs
StatePublished - Feb 2000
Externally publishedYes

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ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology

Cite this

Gilmartin, R., Bruce, D., Storrs, B. B., Abbott, R., Krach, L., Ward, J., Bloom, K., Brooks, W. H., Johnson, D. L., Madsen, J. R., McLaughlin, J. F., & Nadell, J. (2000). Intrathecal baclofen for management of spastic cerebral palsy: Multicenter trial. Journal of Child Neurology, 15(2), 71-77. https://doi.org/10.1177/088307380001500201