TY - JOUR
T1 - Intranuclear "paramyxovirus-like" material in multiple sclerosis, adreno-leukodystrophy and Kuf's disease
AU - Raine, Cedric S.
AU - Schaumburg, Herbert H.
AU - Snyder, David H.
AU - Suzuki, Kinuko
N1 - Funding Information:
This work was supported by USPHS Grants NS-08952, NS-03356, NS-05275 and NS-10803, National Multiple Sclerosis Society Grant 920-A-3. and a grant from the Alfred P. Sloan Foundation. Dr. Raine is the recipient of a Research Career Development Award from the USPHS, Grant NS-70265.
PY - 1975/5
Y1 - 1975/5
N2 - Detailed comparative ultrastructural examination of multiple sclerosis (MS) plaques. inflammatory CNS lesions from adreno-leukodystrophy (A-LD), tissue from a case of chronic granulomatous meningitis, biopsy samples of necrotic cerebral cortex and CNS tissue from a case of Kuf's disease (adult-type ceroid lipofuscinosis), has revealed that the intranuclear filamentous material previously thought to be related to a viral infection in MS in a non-specific finding. These intranuclear strands were, however, found in greatest frequency in the acute lesions of MS and were absent from chronically demyelinated areas. The macrophages, lymphocytes and fibrocytes containing filamentous material in the nuclei were mainly perivascular. In A-LD, some macrophages in active lesions contained similar nuclei, and in Kuf's disease they were present in some glial in the cerebral cortex.
AB - Detailed comparative ultrastructural examination of multiple sclerosis (MS) plaques. inflammatory CNS lesions from adreno-leukodystrophy (A-LD), tissue from a case of chronic granulomatous meningitis, biopsy samples of necrotic cerebral cortex and CNS tissue from a case of Kuf's disease (adult-type ceroid lipofuscinosis), has revealed that the intranuclear filamentous material previously thought to be related to a viral infection in MS in a non-specific finding. These intranuclear strands were, however, found in greatest frequency in the acute lesions of MS and were absent from chronically demyelinated areas. The macrophages, lymphocytes and fibrocytes containing filamentous material in the nuclei were mainly perivascular. In A-LD, some macrophages in active lesions contained similar nuclei, and in Kuf's disease they were present in some glial in the cerebral cortex.
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U2 - 10.1016/0022-510X(75)90184-7
DO - 10.1016/0022-510X(75)90184-7
M3 - Article
C2 - 167131
AN - SCOPUS:0016790037
SN - 0022-510X
VL - 25
SP - 29
EP - 41
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 1
ER -