Intranigral GABAergic drug effects on striatal dopamine activity

E. F. Sperber, J. N.D. Wurpel, N. S. Sharpless, S. L. Moshé

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Concentrations of striatal dopamine (DA), serotonin (5-HT) and their metabolites were measured following infusions ofthe GABAA receptor agonist, muscimol, or GABAA receptor antagonist, bicuculline, into the substantia nigra (SN) or areas dorsal to the SN in adult rats and 16-day-old rat pups. Results indicated that intranigral infusions of muscimol produced site-specific increases in the concentrations of striatal DA metabolites in adults, while in pups, intranigral muscimol infusions produced site-specific increases in the concentrations of striatal DA. Intranigral infusions of bicuculline had no effect on striatal DA or its metabolites in either age group. Neither GABAergic drug had any effect on striatal 5-HT or its metabolite. The data suggest that the effect of nigral GABAA agonist infusions on the activity of the nigrostriatal pathway is age-specific. The lack of opposing effects following the nigral infusion of a GABAA receptor antagonist indicates that the influences of GABAA agonist may be mediated by different mechanisms as a function of age.

Original languageEnglish (US)
Pages (from-to)1067-1070
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Issue number4
StatePublished - Apr 1989


  • Animal newborn
  • Dopamine
  • GABA
  • Rat
  • Seizures
  • Striatum
  • Substantia nigra

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience


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