Intranigral GABAergic drug effects on striatal dopamine activity

E. F. Sperber, J. N D Wurpel, N. S. Sharpless, Solomon L. Moshe

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Concentrations of striatal dopamine (DA), serotonin (5-HT) and their metabolites were measured following infusions ofthe GABAA receptor agonist, muscimol, or GABAA receptor antagonist, bicuculline, into the substantia nigra (SN) or areas dorsal to the SN in adult rats and 16-day-old rat pups. Results indicated that intranigral infusions of muscimol produced site-specific increases in the concentrations of striatal DA metabolites in adults, while in pups, intranigral muscimol infusions produced site-specific increases in the concentrations of striatal DA. Intranigral infusions of bicuculline had no effect on striatal DA or its metabolites in either age group. Neither GABAergic drug had any effect on striatal 5-HT or its metabolite. The data suggest that the effect of nigral GABAA agonist infusions on the activity of the nigrostriatal pathway is age-specific. The lack of opposing effects following the nigral infusion of a GABAA receptor antagonist indicates that the influences of GABAA agonist may be mediated by different mechanisms as a function of age.

Original languageEnglish (US)
Pages (from-to)1067-1070
Number of pages4
JournalPharmacology, Biochemistry and Behavior
Volume32
Issue number4
DOIs
StatePublished - 1989

Fingerprint

GABA Agents
Corpus Striatum
Metabolites
GABA-A Receptor Agonists
Substantia Nigra
Dopamine
GABA-A Receptor Antagonists
Serotonin
Muscimol
Bicuculline
Pharmaceutical Preparations
Rats
GABA-A Receptors
Age Groups

Keywords

  • Animal newborn
  • Dopamine
  • GABA
  • Rat
  • Seizures
  • Striatum
  • Substantia nigra

ASJC Scopus subject areas

  • Biochemistry
  • Behavioral Neuroscience
  • Pharmacology

Cite this

Intranigral GABAergic drug effects on striatal dopamine activity. / Sperber, E. F.; Wurpel, J. N D; Sharpless, N. S.; Moshe, Solomon L.

In: Pharmacology, Biochemistry and Behavior, Vol. 32, No. 4, 1989, p. 1067-1070.

Research output: Contribution to journalArticle

Sperber, E. F. ; Wurpel, J. N D ; Sharpless, N. S. ; Moshe, Solomon L. / Intranigral GABAergic drug effects on striatal dopamine activity. In: Pharmacology, Biochemistry and Behavior. 1989 ; Vol. 32, No. 4. pp. 1067-1070.
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