Intranasal budesonide spray as an adjunct to oral antibiotic therapy for acute sinusitis in children

Işil B. Barlan, Elif Erkan, Mustafa Bakir, Su Berrak, M. Müjdat Başaran

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

Background: The role of topical corticosteroids in the treatment of acute sinusitis has not been established in children. Objective: An attempt was made to determine the impact of topical corticosteroids as an adjunct to antibiotic treatment in the management of childhood sinusitis. Methods: In a double-blind, placebo-controlled study, 151 children with sinusitis were recruited from a general pediatric outpatient clinic and 89 completed a 3- week trial. Treatment consisted of amoxicillin-clavulanate potassium, 40 mg/kg/d tid, combined with bid nasal spray of either budesonide, 50 μg, to each nostril (n = 43) or placebo (n = 46) for 3 weeks. Patients maintained daily symptom cards throughout the study and were examined by the same physician each week. Results: Clinical symptoms and signs decreased significantly in both treatment groups in comparison to baseline (P < .01). We detected a significant improvement in the scores of the cough and nasal discharge at the end of second week in the budesonide group when compared with placebo (P < .05). Friedman nonparametric repeated measures ANOVA test revealed a significant decrease in the total weekly scores of cough during the second week of budesonide treatment (P < .001) in contrast to continuous decline during the second and third weeks in the placebo group (P < .001 and P < .05, respectively). While the nasal discharge score decreased significantly during the second week in the budesonide group (P < .01), no significant effect on the nasal discharge score was observed in the placebo group. Conclusion: These data suggest that topical corticosteroids may be a useful ancillary treatment to antibiotics in childhood sinusitis and effective in reducing the cough and nasal discharge earlier in the course of acute sinusitis.

Original languageEnglish (US)
Pages (from-to)598-601
Number of pages4
JournalAnnals of Allergy, Asthma and Immunology
Volume78
Issue number6
StatePublished - Jun 1997
Externally publishedYes

Fingerprint

Budesonide
Sinusitis
Anti-Bacterial Agents
Nose
Placebos
Cough
Adrenal Cortex Hormones
Therapeutics
Nasal Sprays
Clavulanic Acid
Amoxicillin
Ambulatory Care Facilities
Signs and Symptoms
Analysis of Variance
Pediatrics
Physicians

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Barlan, I. B., Erkan, E., Bakir, M., Berrak, S., & Başaran, M. M. (1997). Intranasal budesonide spray as an adjunct to oral antibiotic therapy for acute sinusitis in children. Annals of Allergy, Asthma and Immunology, 78(6), 598-601.

Intranasal budesonide spray as an adjunct to oral antibiotic therapy for acute sinusitis in children. / Barlan, Işil B.; Erkan, Elif; Bakir, Mustafa; Berrak, Su; Başaran, M. Müjdat.

In: Annals of Allergy, Asthma and Immunology, Vol. 78, No. 6, 06.1997, p. 598-601.

Research output: Contribution to journalArticle

Barlan, IB, Erkan, E, Bakir, M, Berrak, S & Başaran, MM 1997, 'Intranasal budesonide spray as an adjunct to oral antibiotic therapy for acute sinusitis in children', Annals of Allergy, Asthma and Immunology, vol. 78, no. 6, pp. 598-601.
Barlan, Işil B. ; Erkan, Elif ; Bakir, Mustafa ; Berrak, Su ; Başaran, M. Müjdat. / Intranasal budesonide spray as an adjunct to oral antibiotic therapy for acute sinusitis in children. In: Annals of Allergy, Asthma and Immunology. 1997 ; Vol. 78, No. 6. pp. 598-601.
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