Intramyocardial transplantation of cardiac telocytes decreases myocardial infarction and improves post-infarcted cardiac function in rats

Baoyin Zhao, Zhaofu Liao, Shang Chen, Ziqiang Yuan, Chen Yilin, Kenneth K.H. Lee, Xufeng Qi, Xiaotao Shen, Xin Zheng, Thomas Quinn, Dongqing Cai

Research output: Contribution to journalArticlepeer-review

75 Scopus citations

Abstract

The midterm effects of cardiac telocytes (CTs) transplantation on myocardial infarction (MI) and the cellular mechanisms involved in the beneficial effects of CTs transplantation are not understood. In the present study, we have revealed that transplantation of CTs was able to significantly decrease the infarct size and improved cardiac function 14 weeks after MI. It has established that CT transplantation exerted a protective effect on the myocardium and this was maintained for at least 14 weeks. The cellular mechanism behind this beneficial effect on MI was partially attributed to increased cardiac angiogenesis, improved reconstruction of the CT network and decreased myocardial fibrosis. These combined effects decreased the infarct size, improved the reconstruction of the LV and enhanced myocardial function in MI. Our findings suggest that CTs could be considered as a potential cell source for therapeutic use to improve cardiac repair and function following MI, used either alone or in tandem with stem cells.

Original languageEnglish (US)
Pages (from-to)780-789
Number of pages10
JournalJournal of Cellular and Molecular Medicine
Volume18
Issue number5
DOIs
StatePublished - May 2014

Keywords

  • Cardiac telocytes
  • Myocardial infarction
  • Post-infarction cardiac function

ASJC Scopus subject areas

  • Molecular Medicine
  • Cell Biology

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