Intracranial pressure waves: Characterization of a pulsation absorber with notch filter properties using systems analysis - Laboratory investigation

Rui Zou, Eun Hyoung Park, Erin McCormack Kelly, Michael Egnor, Mark E. Wagshul, Joseph R. Madsen

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Object. The relationship between the waveform of intracranial pressure (ICP) and arterial blood pressure can be quantitatively characterized using a newly developed technique in systems analysis, the time-varying transfer function. This technique considers the arterial blood pressure as an input signal composed of multiple frequencies represented in the output ICP according to the transfer function imposed by the intracranial system on the input signal. The transfer function can change with time and with physiological manipulations. The authors examined data obtained from canine experiments involving manipulations of ICP. Methods. The authors analyzed 11 experiments from 3 normal mongrel dogs under conditions of normal ICP and with changes in ICP made by bolus injection, infusion, or withdrawal of cerebrospinal fluid by using time-varying transfer function. Results. During normal ICP periods, the gain of the transfer function displayed a deep notch (≥ 1 log unit) centered at or near the cardiac frequency. In systems terms, the intracranial compartment under normal conditions appears to act as a notch filter attenuating the cardiac frequency input relative to other frequencies. Epochs of ICP elevation showed suppression of the notch, and the notch was restored when ICP returned to normal. Conclusions. The intracranial system in these animals could be considered to include a pulsation absorber for which the target frequency appears to be close to the cardiac frequency. One possible source for such an absorber mechanism might be the free movement of cerebrospinal fluid, implying that impairment of this motion may have important clinical implications in various neurological conditions such as hydrocephalus.

Original languageEnglish (US)
Pages (from-to)83-94
Number of pages12
JournalJournal of Neurosurgery: Pediatrics
Volume2
Issue number1
DOIs
StatePublished - Jul 2008
Externally publishedYes

Fingerprint

Intracranial Pressure
Systems Analysis
Cerebrospinal Fluid
Arterial Pressure
Intracranial Hypertension
Hydrocephalus
Canidae
Dogs
Injections

Keywords

  • Arterial blood pressure
  • Hydrocephalus
  • Intracranial pressure
  • Pulsatility
  • Pulsation absorber
  • Transfer function analysis

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

Intracranial pressure waves : Characterization of a pulsation absorber with notch filter properties using systems analysis - Laboratory investigation. / Zou, Rui; Park, Eun Hyoung; Kelly, Erin McCormack; Egnor, Michael; Wagshul, Mark E.; Madsen, Joseph R.

In: Journal of Neurosurgery: Pediatrics, Vol. 2, No. 1, 07.2008, p. 83-94.

Research output: Contribution to journalArticle

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