Intracranial oculomotor nerve paresis with anisocoria and pupillary parasympathetic hypersensitivity

Thomas L. Slamovits, Neil R. Miller, Ronald M. Burde

Research output: Contribution to journalArticle

12 Scopus citations


Three patients developed anisocoria as a result of third nerve palsies caused by intracranial lesions: two in the cavernous sinus and one in the mesencephalon. Pharmacologic testing using low concentration pilocarpine showed apparent preganglionic parasympathetic supersensitivity of the abnormal pupil. These findings are compatible with the existence of a proposed direct pathway from the midbrain to the eye, without synapse at the ciliary ganglion. Cholinergic hypersensitivity can occur, not only with postciliary ganglionic but also with preciliary ganglionic parasympathetic lesions.

Original languageEnglish (US)
Pages (from-to)401-406
Number of pages6
JournalAmerican journal of ophthalmology
Issue number4
Publication statusPublished - Oct 15 1987
Externally publishedYes


ASJC Scopus subject areas

  • Ophthalmology

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