Intracranial aneurysms: Detection and characterization with MR angiography with use of an advanced postprocessing technique in a blinded- reader study

Scott W. Atlas, Lisa Sheppard, Herbert I. Goldberg, Robert W. Hurst, John Listerud, Eugene S. Flamm

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

PURPOSE: To assess magnetic resonance (MR) angiography for the detection and characterization of angiographically proved intracranial aneurysms by using an advanced method of postprocessing, in a blinded-reader study. MATERIALS AND METHODS: One hundred fifty-eight vessels were examined with catheter angiography and three-dimensional time-of-flight MR angiography in 44 patients with 63 aneurysms and 15 patients with no aneurysm at catheter angiography. Postprocessing was performed off-line with an advanced multifeature-extraction, ray-tracing algorithm. MR angiograms were interpreted independently by three neuroradiologists blinded to the catheter angiographic results for presence, location, size, and morphology of the aneurysm. Proof of diagnosis was consensus reading of catheter angiograms. RESULTS: Mean sensitivity for detection of aneurysms was 75% (range, 70%- 79%). As a screening tool (ie, detection of at least one aneurysm necessitating catheter angiography), mean sensitivity was 91% for all aneurysms and 95% for aneurysms larger than 3 mm. This method was not adequate for detection of lobulation or size of aneurysm. CONCLUSION: MR angiography with an advanced method of postprocessing can result in highly sensitive, specific studies for the diagnosis of intracranial aneurysms that are of sufficient size to be considered for surgical treatment, but it is inadequate for characterization of aneurysms.

Original languageEnglish (US)
Pages (from-to)807-814
Number of pages8
JournalRadiology
Volume203
Issue number3
StatePublished - Jun 1997
Externally publishedYes

Fingerprint

Magnetic Resonance Angiography
Intracranial Aneurysm
Aneurysm
Angiography
Catheters
Reading
Magnetic Resonance Spectroscopy

Keywords

  • Aneurysm, intracranial
  • Brain, MR
  • Cerebral blood vessels, diseases
  • Magnetic resonance (MR), reconstruction algorithms
  • Magnetic resonance (MR), three-dimensional
  • Magnetic resonance (MR), vascular studies

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Intracranial aneurysms : Detection and characterization with MR angiography with use of an advanced postprocessing technique in a blinded- reader study. / Atlas, Scott W.; Sheppard, Lisa; Goldberg, Herbert I.; Hurst, Robert W.; Listerud, John; Flamm, Eugene S.

In: Radiology, Vol. 203, No. 3, 06.1997, p. 807-814.

Research output: Contribution to journalArticle

Atlas, Scott W. ; Sheppard, Lisa ; Goldberg, Herbert I. ; Hurst, Robert W. ; Listerud, John ; Flamm, Eugene S. / Intracranial aneurysms : Detection and characterization with MR angiography with use of an advanced postprocessing technique in a blinded- reader study. In: Radiology. 1997 ; Vol. 203, No. 3. pp. 807-814.
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AU - Sheppard, Lisa

AU - Goldberg, Herbert I.

AU - Hurst, Robert W.

AU - Listerud, John

AU - Flamm, Eugene S.

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N2 - PURPOSE: To assess magnetic resonance (MR) angiography for the detection and characterization of angiographically proved intracranial aneurysms by using an advanced method of postprocessing, in a blinded-reader study. MATERIALS AND METHODS: One hundred fifty-eight vessels were examined with catheter angiography and three-dimensional time-of-flight MR angiography in 44 patients with 63 aneurysms and 15 patients with no aneurysm at catheter angiography. Postprocessing was performed off-line with an advanced multifeature-extraction, ray-tracing algorithm. MR angiograms were interpreted independently by three neuroradiologists blinded to the catheter angiographic results for presence, location, size, and morphology of the aneurysm. Proof of diagnosis was consensus reading of catheter angiograms. RESULTS: Mean sensitivity for detection of aneurysms was 75% (range, 70%- 79%). As a screening tool (ie, detection of at least one aneurysm necessitating catheter angiography), mean sensitivity was 91% for all aneurysms and 95% for aneurysms larger than 3 mm. This method was not adequate for detection of lobulation or size of aneurysm. CONCLUSION: MR angiography with an advanced method of postprocessing can result in highly sensitive, specific studies for the diagnosis of intracranial aneurysms that are of sufficient size to be considered for surgical treatment, but it is inadequate for characterization of aneurysms.

AB - PURPOSE: To assess magnetic resonance (MR) angiography for the detection and characterization of angiographically proved intracranial aneurysms by using an advanced method of postprocessing, in a blinded-reader study. MATERIALS AND METHODS: One hundred fifty-eight vessels were examined with catheter angiography and three-dimensional time-of-flight MR angiography in 44 patients with 63 aneurysms and 15 patients with no aneurysm at catheter angiography. Postprocessing was performed off-line with an advanced multifeature-extraction, ray-tracing algorithm. MR angiograms were interpreted independently by three neuroradiologists blinded to the catheter angiographic results for presence, location, size, and morphology of the aneurysm. Proof of diagnosis was consensus reading of catheter angiograms. RESULTS: Mean sensitivity for detection of aneurysms was 75% (range, 70%- 79%). As a screening tool (ie, detection of at least one aneurysm necessitating catheter angiography), mean sensitivity was 91% for all aneurysms and 95% for aneurysms larger than 3 mm. This method was not adequate for detection of lobulation or size of aneurysm. CONCLUSION: MR angiography with an advanced method of postprocessing can result in highly sensitive, specific studies for the diagnosis of intracranial aneurysms that are of sufficient size to be considered for surgical treatment, but it is inadequate for characterization of aneurysms.

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