Intracranial aneurysms: Detection and characterization with MR angiography with use of an advanced postprocessing technique in a blinded- reader study

Scott W. Atlas, Lisa Sheppard, Herbert I. Goldberg, Robert W. Hurst, John Listerud, Eugene Flamm

Research output: Contribution to journalArticle

79 Scopus citations


PURPOSE: To assess magnetic resonance (MR) angiography for the detection and characterization of angiographically proved intracranial aneurysms by using an advanced method of postprocessing, in a blinded-reader study. MATERIALS AND METHODS: One hundred fifty-eight vessels were examined with catheter angiography and three-dimensional time-of-flight MR angiography in 44 patients with 63 aneurysms and 15 patients with no aneurysm at catheter angiography. Postprocessing was performed off-line with an advanced multifeature-extraction, ray-tracing algorithm. MR angiograms were interpreted independently by three neuroradiologists blinded to the catheter angiographic results for presence, location, size, and morphology of the aneurysm. Proof of diagnosis was consensus reading of catheter angiograms. RESULTS: Mean sensitivity for detection of aneurysms was 75% (range, 70%- 79%). As a screening tool (ie, detection of at least one aneurysm necessitating catheter angiography), mean sensitivity was 91% for all aneurysms and 95% for aneurysms larger than 3 mm. This method was not adequate for detection of lobulation or size of aneurysm. CONCLUSION: MR angiography with an advanced method of postprocessing can result in highly sensitive, specific studies for the diagnosis of intracranial aneurysms that are of sufficient size to be considered for surgical treatment, but it is inadequate for characterization of aneurysms.

Original languageEnglish (US)
Pages (from-to)807-814
Number of pages8
Issue number3
Publication statusPublished - Jun 1997
Externally publishedYes



  • Aneurysm, intracranial
  • Brain, MR
  • Cerebral blood vessels, diseases
  • Magnetic resonance (MR), reconstruction algorithms
  • Magnetic resonance (MR), three-dimensional
  • Magnetic resonance (MR), vascular studies

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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