Intracerebroventricular CART peptide reduces food intake and alters motor behavior at a hindbrain site

Susan Aja, Shirin Sahandy, Ellen E. Ladenheim, Gary J. Schwartz, Timothy H. Moran

Research output: Contribution to journalArticle

69 Citations (Scopus)

Abstract

Peptides from cocaine- and amphetamine-regulated transcript (CART) reduce food intake in rats when injected into the lateral ventricle. Hypothalamic and hindbrain sites important in the control of feeding contain CART-immunoreactive fibers. To further define the site of CART's anorectic action, we compared feeding and other behavioral responses to third or fourth ventricular (3V, 4V) CART-(55-102) in 6-h food-deprived rats, both before and after cerebral aqueduct occlusion. 3V CART reduced the volume of Ensure consumed and resulted in fewer observations of eating and grooming within the 30-min test session. These reductions were significantly attenuated by aqueduct obstruction. 4V CART suppressed Ensure intake and resulted in decreased observations of feeding both with and without aqueduct blockade. 3V CART produced flat-backed postures and movement-associated tremors that were prevented by aqueduct obstruction. 4V CART also produced these signs, both with and without aqueduct blockade. We conclude that the major hypophagic effect of intracerebroventricular CART is mediated at a hindbrain site. The association of CART-induced feeding suppression with altered motor behavior questions the specificity of intracerebroventricular CART for actions on feeding.

Original languageEnglish (US)
JournalAmerican Journal of Physiology
Volume281
Issue number6 PART 2
StatePublished - Dec 2001
Externally publishedYes

Fingerprint

Rhombencephalon
Amphetamine
Cocaine
Eating
Peptides
Cerebral Aqueduct
Appetite Depressants
Grooming
Lateral Ventricles
Tremor
Posture
Food

Keywords

  • Cocaine- and amphetamine-regulated transcript feeding
  • Hypothalamus

ASJC Scopus subject areas

  • Physiology (medical)

Cite this

Intracerebroventricular CART peptide reduces food intake and alters motor behavior at a hindbrain site. / Aja, Susan; Sahandy, Shirin; Ladenheim, Ellen E.; Schwartz, Gary J.; Moran, Timothy H.

In: American Journal of Physiology, Vol. 281, No. 6 PART 2, 12.2001.

Research output: Contribution to journalArticle

Aja, Susan ; Sahandy, Shirin ; Ladenheim, Ellen E. ; Schwartz, Gary J. ; Moran, Timothy H. / Intracerebroventricular CART peptide reduces food intake and alters motor behavior at a hindbrain site. In: American Journal of Physiology. 2001 ; Vol. 281, No. 6 PART 2.
@article{1f980e5c1c854885834c3c5a772eca3d,
title = "Intracerebroventricular CART peptide reduces food intake and alters motor behavior at a hindbrain site",
abstract = "Peptides from cocaine- and amphetamine-regulated transcript (CART) reduce food intake in rats when injected into the lateral ventricle. Hypothalamic and hindbrain sites important in the control of feeding contain CART-immunoreactive fibers. To further define the site of CART's anorectic action, we compared feeding and other behavioral responses to third or fourth ventricular (3V, 4V) CART-(55-102) in 6-h food-deprived rats, both before and after cerebral aqueduct occlusion. 3V CART reduced the volume of Ensure consumed and resulted in fewer observations of eating and grooming within the 30-min test session. These reductions were significantly attenuated by aqueduct obstruction. 4V CART suppressed Ensure intake and resulted in decreased observations of feeding both with and without aqueduct blockade. 3V CART produced flat-backed postures and movement-associated tremors that were prevented by aqueduct obstruction. 4V CART also produced these signs, both with and without aqueduct blockade. We conclude that the major hypophagic effect of intracerebroventricular CART is mediated at a hindbrain site. The association of CART-induced feeding suppression with altered motor behavior questions the specificity of intracerebroventricular CART for actions on feeding.",
keywords = "Cocaine- and amphetamine-regulated transcript feeding, Hypothalamus",
author = "Susan Aja and Shirin Sahandy and Ladenheim, {Ellen E.} and Schwartz, {Gary J.} and Moran, {Timothy H.}",
year = "2001",
month = "12",
language = "English (US)",
volume = "281",
journal = "American Journal of Physiology - Renal Physiology",
issn = "1931-857X",
publisher = "American Physiological Society",
number = "6 PART 2",

}

TY - JOUR

T1 - Intracerebroventricular CART peptide reduces food intake and alters motor behavior at a hindbrain site

AU - Aja, Susan

AU - Sahandy, Shirin

AU - Ladenheim, Ellen E.

AU - Schwartz, Gary J.

AU - Moran, Timothy H.

PY - 2001/12

Y1 - 2001/12

N2 - Peptides from cocaine- and amphetamine-regulated transcript (CART) reduce food intake in rats when injected into the lateral ventricle. Hypothalamic and hindbrain sites important in the control of feeding contain CART-immunoreactive fibers. To further define the site of CART's anorectic action, we compared feeding and other behavioral responses to third or fourth ventricular (3V, 4V) CART-(55-102) in 6-h food-deprived rats, both before and after cerebral aqueduct occlusion. 3V CART reduced the volume of Ensure consumed and resulted in fewer observations of eating and grooming within the 30-min test session. These reductions were significantly attenuated by aqueduct obstruction. 4V CART suppressed Ensure intake and resulted in decreased observations of feeding both with and without aqueduct blockade. 3V CART produced flat-backed postures and movement-associated tremors that were prevented by aqueduct obstruction. 4V CART also produced these signs, both with and without aqueduct blockade. We conclude that the major hypophagic effect of intracerebroventricular CART is mediated at a hindbrain site. The association of CART-induced feeding suppression with altered motor behavior questions the specificity of intracerebroventricular CART for actions on feeding.

AB - Peptides from cocaine- and amphetamine-regulated transcript (CART) reduce food intake in rats when injected into the lateral ventricle. Hypothalamic and hindbrain sites important in the control of feeding contain CART-immunoreactive fibers. To further define the site of CART's anorectic action, we compared feeding and other behavioral responses to third or fourth ventricular (3V, 4V) CART-(55-102) in 6-h food-deprived rats, both before and after cerebral aqueduct occlusion. 3V CART reduced the volume of Ensure consumed and resulted in fewer observations of eating and grooming within the 30-min test session. These reductions were significantly attenuated by aqueduct obstruction. 4V CART suppressed Ensure intake and resulted in decreased observations of feeding both with and without aqueduct blockade. 3V CART produced flat-backed postures and movement-associated tremors that were prevented by aqueduct obstruction. 4V CART also produced these signs, both with and without aqueduct blockade. We conclude that the major hypophagic effect of intracerebroventricular CART is mediated at a hindbrain site. The association of CART-induced feeding suppression with altered motor behavior questions the specificity of intracerebroventricular CART for actions on feeding.

KW - Cocaine- and amphetamine-regulated transcript feeding

KW - Hypothalamus

UR - http://www.scopus.com/inward/record.url?scp=0035658557&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035658557&partnerID=8YFLogxK

M3 - Article

VL - 281

JO - American Journal of Physiology - Renal Physiology

JF - American Journal of Physiology - Renal Physiology

SN - 1931-857X

IS - 6 PART 2

ER -