Intracellular degradation of HeLa and adenovirus type 2 DNA induced by camptothecin

Marshall S. Horwitz, Susan Band Horwitz

Research output: Contribution to journalArticle

96 Citations (Scopus)

Abstract

The addition of camptothecin, an inhibitor of nucleic acid synthesis, to HeLa cells or adenovirus-infected HeLa cells results in the partial degradation of cellular and viral DNA. There is no detectable release of acid soluble nucleotides.

Original languageEnglish (US)
Pages (from-to)723-727
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume45
Issue number3
DOIs
StatePublished - Nov 5 1971

Fingerprint

Nucleic Acid Synthesis Inhibitors
Camptothecin
Viral DNA
HeLa Cells
Adenoviridae
Nucleotides
Degradation
Acids
DNA

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

Cite this

Intracellular degradation of HeLa and adenovirus type 2 DNA induced by camptothecin. / Horwitz, Marshall S.; Band Horwitz, Susan.

In: Biochemical and Biophysical Research Communications, Vol. 45, No. 3, 05.11.1971, p. 723-727.

Research output: Contribution to journalArticle

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