Intracellular degradation of HeLa and adenovirus type 2 DNA induced by camptothecin

Marshall S. Horwitz, Susan B. Horwitz

Research output: Contribution to journalArticle

97 Scopus citations

Abstract

The addition of camptothecin, an inhibitor of nucleic acid synthesis, to HeLa cells or adenovirus-infected HeLa cells results in the partial degradation of cellular and viral DNA. There is no detectable release of acid soluble nucleotides.

Original languageEnglish (US)
Pages (from-to)723-727
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume45
Issue number3
DOIs
StatePublished - Nov 5 1971

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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