Intracellular crystal formation as a mechanism of cytotoxicity in murine pulmonary Cryptococcus neoformans infection

M. Feldmesser, Y. Kress, A. Casadevall

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Rod-like crystalline structures formed during eosinophilic Cryptococcus neoformans pneumonia in C57BL/6 mice. Crystals were found associated with yeast cells and free in host cell cytoplasm. The crystals apparently formed because of the interaction of a host protein with the cryptococcal polysaccharide. Crystal formation likely contributes to pathogenesis by causing cellular damage.

Original languageEnglish (US)
Pages (from-to)2723-2727
Number of pages5
JournalInfection and immunity
Volume69
Issue number4
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

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