Intracellular crystal formation as a mechanism of cytotoxicity in murine pulmonary Cryptococcus neoformans infection

M. Feldmesser, Y. Kress, A. Casadevall

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Rod-like crystalline structures formed during eosinophilic Cryptococcus neoformans pneumonia in C57BL/6 mice. Crystals were found associated with yeast cells and free in host cell cytoplasm. The crystals apparently formed because of the interaction of a host protein with the cryptococcal polysaccharide. Crystal formation likely contributes to pathogenesis by causing cellular damage.

Original languageEnglish (US)
Pages (from-to)2723-2727
Number of pages5
JournalInfection and Immunity
Volume69
Issue number4
DOIs
StatePublished - 2001

Fingerprint

Cryptococcus neoformans
Lung
Infection
Inbred C57BL Mouse
Pneumonia
Cytoplasm
Yeasts
Proteins
cryptococcal polysaccharide

ASJC Scopus subject areas

  • Immunology

Cite this

Intracellular crystal formation as a mechanism of cytotoxicity in murine pulmonary Cryptococcus neoformans infection. / Feldmesser, M.; Kress, Y.; Casadevall, A.

In: Infection and Immunity, Vol. 69, No. 4, 2001, p. 2723-2727.

Research output: Contribution to journalArticle

@article{fb793c650f774213803ab51a7f6fde94,
title = "Intracellular crystal formation as a mechanism of cytotoxicity in murine pulmonary Cryptococcus neoformans infection",
abstract = "Rod-like crystalline structures formed during eosinophilic Cryptococcus neoformans pneumonia in C57BL/6 mice. Crystals were found associated with yeast cells and free in host cell cytoplasm. The crystals apparently formed because of the interaction of a host protein with the cryptococcal polysaccharide. Crystal formation likely contributes to pathogenesis by causing cellular damage.",
author = "M. Feldmesser and Y. Kress and A. Casadevall",
year = "2001",
doi = "10.1128/IAI.69.4.2723-2727.2001",
language = "English (US)",
volume = "69",
pages = "2723--2727",
journal = "Infection and Immunity",
issn = "0019-9567",
publisher = "American Society for Microbiology",
number = "4",

}

TY - JOUR

T1 - Intracellular crystal formation as a mechanism of cytotoxicity in murine pulmonary Cryptococcus neoformans infection

AU - Feldmesser, M.

AU - Kress, Y.

AU - Casadevall, A.

PY - 2001

Y1 - 2001

N2 - Rod-like crystalline structures formed during eosinophilic Cryptococcus neoformans pneumonia in C57BL/6 mice. Crystals were found associated with yeast cells and free in host cell cytoplasm. The crystals apparently formed because of the interaction of a host protein with the cryptococcal polysaccharide. Crystal formation likely contributes to pathogenesis by causing cellular damage.

AB - Rod-like crystalline structures formed during eosinophilic Cryptococcus neoformans pneumonia in C57BL/6 mice. Crystals were found associated with yeast cells and free in host cell cytoplasm. The crystals apparently formed because of the interaction of a host protein with the cryptococcal polysaccharide. Crystal formation likely contributes to pathogenesis by causing cellular damage.

UR - http://www.scopus.com/inward/record.url?scp=0035083052&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035083052&partnerID=8YFLogxK

U2 - 10.1128/IAI.69.4.2723-2727.2001

DO - 10.1128/IAI.69.4.2723-2727.2001

M3 - Article

C2 - 11254641

AN - SCOPUS:0035083052

VL - 69

SP - 2723

EP - 2727

JO - Infection and Immunity

JF - Infection and Immunity

SN - 0019-9567

IS - 4

ER -