Intracellular calcium release channels: an update

Gaetano Santulli, Ryutaro Nakashima, Qi Yuan, Andrew R. Marks

Research output: Contribution to journalReview articlepeer-review

162 Scopus citations

Abstract

Ryanodine receptors (RyRs) and inositol 1,4,5-trisphosphate receptors (IP3Rs) are calcium (Ca2+) release channels on the endo/sarcoplasmic reticulum (ER/SR). Here we summarize the latest advances in the field, describing the recently discovered mechanistic roles of intracellular Ca2+ release channels in the regulation of mitochondrial fitness and endothelial function, providing novel therapeutic options for the treatment of heart failure, hypertension, and diabetes mellitus. (Figure presented.).

Original languageEnglish (US)
Pages (from-to)3041-3051
Number of pages11
JournalJournal of Physiology
Volume595
Issue number10
DOIs
StatePublished - May 15 2017
Externally publishedYes

Keywords

  • Calcium
  • Diabetes mellitus
  • Heart failure
  • Hypertension
  • IP3R
  • Intracellular calcium release channels
  • RyR
  • excitation-contraction coupling

ASJC Scopus subject areas

  • Physiology

Fingerprint

Dive into the research topics of 'Intracellular calcium release channels: an update'. Together they form a unique fingerprint.

Cite this