The authors studied the in vitro effect of a calcium-channel-blocker - verapamil, local anesthetic - bupivacaine and a calcium ionophore - A23187 on the permeability of the monolayer mesothelium from the rabbit's mesentery. Verapamil and bupivacaine increased transmesothelial flux of calcium while A23187 increased calcium transport only transiently. Verapamil augmented the permeability of the mesothelium to insulin and urea. However, A23187 decreased the transmesothelial flux of insulin only whereas it increased the transport of urea. From this study we have concluded, that intracellular calcium may determine the permeability of the peritoneal mesothelium.
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