TY - JOUR
T1 - Intracellular calcium ions modulate permeability of the peritoneal mesothelium in vitro
AU - Breborowicz, A.
AU - Knapowski, J.
AU - Breborowicz, G.
PY - 1985
Y1 - 1985
N2 - The authors studied the in vitro effect of a calcium-channel-blocker - verapamil, local anesthetic - bupivacaine and a calcium ionophore - A23187 on the permeability of the monolayer mesothelium from the rabbit's mesentery. Verapamil and bupivacaine increased transmesothelial flux of calcium while A23187 increased calcium transport only transiently. Verapamil augmented the permeability of the mesothelium to insulin and urea. However, A23187 decreased the transmesothelial flux of insulin only whereas it increased the transport of urea. From this study we have concluded, that intracellular calcium may determine the permeability of the peritoneal mesothelium.
AB - The authors studied the in vitro effect of a calcium-channel-blocker - verapamil, local anesthetic - bupivacaine and a calcium ionophore - A23187 on the permeability of the monolayer mesothelium from the rabbit's mesentery. Verapamil and bupivacaine increased transmesothelial flux of calcium while A23187 increased calcium transport only transiently. Verapamil augmented the permeability of the mesothelium to insulin and urea. However, A23187 decreased the transmesothelial flux of insulin only whereas it increased the transport of urea. From this study we have concluded, that intracellular calcium may determine the permeability of the peritoneal mesothelium.
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U2 - 10.1177/089686088500500205
DO - 10.1177/089686088500500205
M3 - Article
AN - SCOPUS:0021876612
SN - 0226-8787
VL - 5
SP - 105
EP - 108
JO - Peritoneal Dialysis Bulletin
JF - Peritoneal Dialysis Bulletin
IS - 2
ER -