Intra-day signal instabilities affect decoding performance in an intracortical neural interface system

János A. Perge, Mark L. Homer, Wasim Q. Malik, Sydney Cash, Emad N. Eskandar, Gerhard Friehs, John P. Donoghue, Leigh R. Hochberg

Research output: Contribution to journalArticle

78 Citations (Scopus)

Abstract

Objective. Motor neural interface systems (NIS) aim to convert neural signals into motor prosthetic or assistive device control, allowing people with paralysis to regain movement or control over their immediate environment. Effector or prosthetic control can degrade if the relationship between recorded neural signals and intended motor behavior changes. Therefore, characterizing both biological and technological sources of signal variability is important for a reliable NIS. Approach. To address the frequency and causes of neural signal variability in a spike-based NIS, we analyzed within-day fluctuations in spiking activity and action potential amplitude recorded with silicon microelectrode arrays implanted in the motor cortex of three people with tetraplegia (BrainGate pilot clinical trial, IDE). Main results. 84% of the recorded units showed a statistically significant change in apparent firing rate (3.8 ± 8.71 Hz or 49% of the mean rate) across several-minute epochs of tasks performed on a single session, and 74% of the units showed a significant change in spike amplitude (3.7 ± 6.5 μV or 5.5% of mean spike amplitude). 40% of the recording sessions showed a significant correlation in the occurrence of amplitude changes across electrodes, suggesting array micro-movement. Despite the relatively frequent amplitude changes, only 15% of the observed within-day rate changes originated from recording artifacts such as spike amplitude change or electrical noise, while 85% of the rate changes most likely emerged from physiological mechanisms. Computer simulations confirmed that systematic rate changes of individual neurons could produce a directional 'bias' in the decoded neural cursor movements. Instability in apparent neuronal spike rates indeed yielded a directional bias in 56% of all performance assessments in participant cursor control (n = 2 participants, 108 and 20 assessments over two years), resulting in suboptimal performance in these sessions. Significance. We anticipate that signal acquisition and decoding methods that can adapt to the reported instabilities will further improve the performance of intracortically-based NISs.

Original languageEnglish (US)
Article number036004
JournalJournal of Neural Engineering
Volume10
Issue number3
DOIs
StatePublished - Jun 1 2013
Externally publishedYes

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Self-Help Devices
Quadriplegia
Motor Cortex
Microelectrodes
Silicon
Paralysis
Computer Simulation
Artifacts
Action Potentials
Decoding
Noise
Electrodes
Clinical Trials
Neurons
Prosthetics
Regain
Computer simulation

ASJC Scopus subject areas

  • Biomedical Engineering
  • Cellular and Molecular Neuroscience

Cite this

Intra-day signal instabilities affect decoding performance in an intracortical neural interface system. / Perge, János A.; Homer, Mark L.; Malik, Wasim Q.; Cash, Sydney; Eskandar, Emad N.; Friehs, Gerhard; Donoghue, John P.; Hochberg, Leigh R.

In: Journal of Neural Engineering, Vol. 10, No. 3, 036004, 01.06.2013.

Research output: Contribution to journalArticle

Perge, János A. ; Homer, Mark L. ; Malik, Wasim Q. ; Cash, Sydney ; Eskandar, Emad N. ; Friehs, Gerhard ; Donoghue, John P. ; Hochberg, Leigh R. / Intra-day signal instabilities affect decoding performance in an intracortical neural interface system. In: Journal of Neural Engineering. 2013 ; Vol. 10, No. 3.
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