Intestinal perforation in very low birth weight infants: Growth and neurodevelopment at 1 year of age

Olubukunola A. Adesanya, T. Michael O'Shea, Charles S. Turner, Robert M. Amoroso, Timothy M. Morgan, Judy L. Aschner

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Objective: To compare growth and neurodevelopment in surviving very low birth weight (VLBW) infants with an intestinal perforation (IP) caused by necrotizing enterocolitis (NEC) versus spontaneous intestinal perforation (SIP). Study Design: Retrospective, observational cohort study. Infants born between January 1996 and December 1999 with birth weight < 1500 g and a diagnosis of intestinal perforation were identified and data extracted from NICU, surgical and hospital databases. Results: IP was identified in 62 of 1357 VLBW infants (5%); 39 infants (63%) had surgical NEC and 23 (37%) had SIP. Among survivors, 21/28 with surgical NEC (75%) and 13/18 with SIP (72%) returned for follow-up. At 1-year adjusted age, there were no differences in growth parameters but the Mental Developmental Index (MDI) and Psychomotor Developmental Index (PDI) were lower in survivors with NEC versus SIP (mean difference in MDI=15; 95% confidence limits=3, 28; p=0.02; mean difference in PDI=14; 95% confidence limits=0.4, 28; p=0.04). Conclusions: Intestinal perforation caused by NEC, as compared to SIP, is associated with worse neurodevelopmental outcome at 1 year.

Original languageEnglish (US)
Pages (from-to)583-589
Number of pages7
JournalJournal of Perinatology
Volume25
Issue number9
DOIs
StatePublished - Sep 2005
Externally publishedYes

Fingerprint

Intestinal Perforation
Very Low Birth Weight Infant
Necrotizing Enterocolitis
Growth
Birth Weight
Observational Studies
Cohort Studies
Retrospective Studies
Spontaneous Perforation
Databases

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Adesanya, O. A., O'Shea, T. M., Turner, C. S., Amoroso, R. M., Morgan, T. M., & Aschner, J. L. (2005). Intestinal perforation in very low birth weight infants: Growth and neurodevelopment at 1 year of age. Journal of Perinatology, 25(9), 583-589. https://doi.org/10.1038/sj.jp.7211360

Intestinal perforation in very low birth weight infants : Growth and neurodevelopment at 1 year of age. / Adesanya, Olubukunola A.; O'Shea, T. Michael; Turner, Charles S.; Amoroso, Robert M.; Morgan, Timothy M.; Aschner, Judy L.

In: Journal of Perinatology, Vol. 25, No. 9, 09.2005, p. 583-589.

Research output: Contribution to journalArticle

Adesanya, OA, O'Shea, TM, Turner, CS, Amoroso, RM, Morgan, TM & Aschner, JL 2005, 'Intestinal perforation in very low birth weight infants: Growth and neurodevelopment at 1 year of age', Journal of Perinatology, vol. 25, no. 9, pp. 583-589. https://doi.org/10.1038/sj.jp.7211360
Adesanya, Olubukunola A. ; O'Shea, T. Michael ; Turner, Charles S. ; Amoroso, Robert M. ; Morgan, Timothy M. ; Aschner, Judy L. / Intestinal perforation in very low birth weight infants : Growth and neurodevelopment at 1 year of age. In: Journal of Perinatology. 2005 ; Vol. 25, No. 9. pp. 583-589.
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