TY - JOUR
T1 - Intestinal perforation in very low birth weight infants
T2 - Growth and neurodevelopment at 1 year of age
AU - Adesanya, Olubukunola A.
AU - O'Shea, T. Michael
AU - Turner, Charles S.
AU - Amoroso, Robert M.
AU - Morgan, Timothy M.
AU - Aschner, Judy L.
N1 - Funding Information:
We thank Nancy Peters for her assistance in identifying study subjects, and Barbara Jackson, Robert Dillard, Kurt Klinepeter and Donald Goldstein for performing follow-up assessments on the study subjects. This study was funded in part by the North Carolina Department of Health and Human Services.
PY - 2005/9
Y1 - 2005/9
N2 - Objective: To compare growth and neurodevelopment in surviving very low birth weight (VLBW) infants with an intestinal perforation (IP) caused by necrotizing enterocolitis (NEC) versus spontaneous intestinal perforation (SIP). Study Design: Retrospective, observational cohort study. Infants born between January 1996 and December 1999 with birth weight < 1500 g and a diagnosis of intestinal perforation were identified and data extracted from NICU, surgical and hospital databases. Results: IP was identified in 62 of 1357 VLBW infants (5%); 39 infants (63%) had surgical NEC and 23 (37%) had SIP. Among survivors, 21/28 with surgical NEC (75%) and 13/18 with SIP (72%) returned for follow-up. At 1-year adjusted age, there were no differences in growth parameters but the Mental Developmental Index (MDI) and Psychomotor Developmental Index (PDI) were lower in survivors with NEC versus SIP (mean difference in MDI=15; 95% confidence limits=3, 28; p=0.02; mean difference in PDI=14; 95% confidence limits=0.4, 28; p=0.04). Conclusions: Intestinal perforation caused by NEC, as compared to SIP, is associated with worse neurodevelopmental outcome at 1 year.
AB - Objective: To compare growth and neurodevelopment in surviving very low birth weight (VLBW) infants with an intestinal perforation (IP) caused by necrotizing enterocolitis (NEC) versus spontaneous intestinal perforation (SIP). Study Design: Retrospective, observational cohort study. Infants born between January 1996 and December 1999 with birth weight < 1500 g and a diagnosis of intestinal perforation were identified and data extracted from NICU, surgical and hospital databases. Results: IP was identified in 62 of 1357 VLBW infants (5%); 39 infants (63%) had surgical NEC and 23 (37%) had SIP. Among survivors, 21/28 with surgical NEC (75%) and 13/18 with SIP (72%) returned for follow-up. At 1-year adjusted age, there were no differences in growth parameters but the Mental Developmental Index (MDI) and Psychomotor Developmental Index (PDI) were lower in survivors with NEC versus SIP (mean difference in MDI=15; 95% confidence limits=3, 28; p=0.02; mean difference in PDI=14; 95% confidence limits=0.4, 28; p=0.04). Conclusions: Intestinal perforation caused by NEC, as compared to SIP, is associated with worse neurodevelopmental outcome at 1 year.
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U2 - 10.1038/sj.jp.7211360
DO - 10.1038/sj.jp.7211360
M3 - Article
C2 - 16034475
AN - SCOPUS:31044452661
SN - 0743-8346
VL - 25
SP - 583
EP - 589
JO - Journal of Perinatology
JF - Journal of Perinatology
IS - 9
ER -