TY - JOUR
T1 - Intestinal Barrier and Permeability in Health, Obesity and NAFLD
AU - Portincasa, Piero
AU - Bonfrate, Leonilde
AU - Khalil, Mohamad
AU - De Angelis, Maria
AU - Calabrese, Francesco Maria
AU - D’amato, Mauro
AU - Wang, David Q.H.
AU - Di Ciaula, Agostino
N1 - Funding Information:
Funding: This paper has been partly supported by funding from the European Union’s Horizon 2020 Research and Innovation program under the Marie Skłodowska-Curie Grant Agreement No. 722619 (FOIE GRAS), Grant Agreement No. 734719 (mtFOIE GRAS) and Grant Regione Puglia, CUP H99C20000340002 (Fever Apulia).
Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/1
Y1 - 2022/1
N2 - The largest surface of the human body exposed to the external environment is the gut. At this level, the intestinal barrier includes luminal microbes, the mucin layer, gastrointestinal motility and secretion, enterocytes, immune cells, gut vascular barrier, and liver barrier. A healthy intestinal barrier is characterized by the selective permeability of nutrients, metabolites, water, and bacterial products, and processes are governed by cellular, neural, immune, and hormonal factors. Disrupted gut permeability (leaky gut syndrome) can represent a predisposing or aggravating condition in obesity and the metabolically associated liver steatosis (nonalcoholic fatty liver disease, NAFLD). In what follows, we describe the morphological-functional features of the intestinal barrier, the role of major modifiers of the intestinal barrier, and discuss the recent evidence pointing to the key role of intestinal permeability in obesity/NAFLD.
AB - The largest surface of the human body exposed to the external environment is the gut. At this level, the intestinal barrier includes luminal microbes, the mucin layer, gastrointestinal motility and secretion, enterocytes, immune cells, gut vascular barrier, and liver barrier. A healthy intestinal barrier is characterized by the selective permeability of nutrients, metabolites, water, and bacterial products, and processes are governed by cellular, neural, immune, and hormonal factors. Disrupted gut permeability (leaky gut syndrome) can represent a predisposing or aggravating condition in obesity and the metabolically associated liver steatosis (nonalcoholic fatty liver disease, NAFLD). In what follows, we describe the morphological-functional features of the intestinal barrier, the role of major modifiers of the intestinal barrier, and discuss the recent evidence pointing to the key role of intestinal permeability in obesity/NAFLD.
KW - Intestine
KW - Metabolic syndrome
KW - Metabolome
KW - Microbiota
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U2 - 10.3390/biomedicines10010083
DO - 10.3390/biomedicines10010083
M3 - Review article
AN - SCOPUS:85122231429
SN - 2227-9059
VL - 10
JO - Biomedicines
JF - Biomedicines
IS - 1
M1 - 83
ER -
