Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription

Vivek Behera; Aaron J. Stonestrom; Nicole Hamagami; Chris C. Hsiung; Cheryl A. Keller; Belinda Giardine; Simone Sidoli; Zuo Fei Yuan; Natarajan V. Bhanu; Michael T. Werner; Hongxin Wang; Benjamin A. Garcia; Ross C. Hardison; Gerd A. Blobel

doi:10.1016/j.celrep.2019.03.057

Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription

Vivek Behera, Aaron J. Stonestrom, Nicole Hamagami, Chris C. Hsiung, Cheryl A. Keller, Belinda Giardine, Simone Sidoli, Zuo Fei Yuan, Natarajan V. Bhanu, Michael T. Werner, Hongxin Wang, Benjamin A. Garcia, Ross C. Hardison, Gerd A. Blobel

Research output: Contribution to journal › Article › peer-review

38 Scopus citations

Abstract

Chromatin reader protein BRD4 is thought to bookmark mitotic chromatin to propagate transcriptional states across mitosis. Behera et al. profiled and perturbed mitotic BRD4 chromatin occupancy to show that BRD4 is dispensable for this process. Instead, BRD4 mitotic chromatin association is likely a mere reflection of mitotically stable histone marks.

Original language	English (US)
Pages (from-to)	400-415.e5
Journal	Cell Reports
Volume	27
Issue number	2
DOIs	https://doi.org/10.1016/j.celrep.2019.03.057
State	Published - Apr 9 2019
Externally published	Yes

Keywords

BRD4
cell identity
erythroid cells
histone marks
mitosis
mitotic bookmarking

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2019.03.057

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title = "Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription",

abstract = "Chromatin reader protein BRD4 is thought to bookmark mitotic chromatin to propagate transcriptional states across mitosis. Behera et al. profiled and perturbed mitotic BRD4 chromatin occupancy to show that BRD4 is dispensable for this process. Instead, BRD4 mitotic chromatin association is likely a mere reflection of mitotically stable histone marks.",

keywords = "BRD4, cell identity, erythroid cells, histone marks, mitosis, mitotic bookmarking",

author = "Vivek Behera and Stonestrom, {Aaron J.} and Nicole Hamagami and Hsiung, {Chris C.} and Keller, {Cheryl A.} and Belinda Giardine and Simone Sidoli and Yuan, {Zuo Fei} and Bhanu, {Natarajan V.} and Werner, {Michael T.} and Hongxin Wang and Garcia, {Benjamin A.} and Hardison, {Ross C.} and Blobel, {Gerd A.}",

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year = "2019",

month = apr,

day = "9",

doi = "10.1016/j.celrep.2019.03.057",

language = "English (US)",

volume = "27",

pages = "400--415.e5",

journal = "Cell Reports",

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publisher = "Cell Press",

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TY - JOUR

T1 - Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription

AU - Behera, Vivek

AU - Stonestrom, Aaron J.

AU - Hamagami, Nicole

AU - Hsiung, Chris C.

AU - Keller, Cheryl A.

AU - Giardine, Belinda

AU - Sidoli, Simone

AU - Yuan, Zuo Fei

AU - Bhanu, Natarajan V.

AU - Werner, Michael T.

AU - Wang, Hongxin

AU - Garcia, Benjamin A.

AU - Hardison, Ross C.

AU - Blobel, Gerd A.

PY - 2019/4/9

Y1 - 2019/4/9

N2 - Chromatin reader protein BRD4 is thought to bookmark mitotic chromatin to propagate transcriptional states across mitosis. Behera et al. profiled and perturbed mitotic BRD4 chromatin occupancy to show that BRD4 is dispensable for this process. Instead, BRD4 mitotic chromatin association is likely a mere reflection of mitotically stable histone marks.

AB - Chromatin reader protein BRD4 is thought to bookmark mitotic chromatin to propagate transcriptional states across mitosis. Behera et al. profiled and perturbed mitotic BRD4 chromatin occupancy to show that BRD4 is dispensable for this process. Instead, BRD4 mitotic chromatin association is likely a mere reflection of mitotically stable histone marks.

KW - BRD4

KW - cell identity

KW - erythroid cells

KW - histone marks

KW - mitosis

KW - mitotic bookmarking

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SP - 400-415.e5

JO - Cell Reports

JF - Cell Reports

IS - 2

ER -

Interrogating Histone Acetylation and BRD4 as Mitotic Bookmarks of Transcription

Abstract

Keywords

ASJC Scopus subject areas

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