International epidemiology databases to evaluate AIDS (IeDEA) in sub-Saharan Africa, 2012-2019

Frédérique Chammartin, Cam Ha Dao Ostinelli, Kathryn Anastos, Antoine Jaquet, Ellen Brazier, Steven Brown, Francois Dabis, Mary Ann Davies, Stephany N. Duda, Karen Malateste, Denis Nash, Kara Wools-Kaloustian, Per M. Von Groote, Matthias Egger

Research output: Contribution to journalReview article

Abstract

Purpose The objectives of the International epidemiology databases to evaluate AIDS (IeDEA) are to (i) evaluate the delivery of combination antiretroviral therapy (ART) in children, adolescents and adults in sub-Saharan Africa, (ii) to describe ART regimen effectiveness, durability and tolerability, (iii) to examine HIV-related comorbidities and coinfections and (iv) to examine the pregnancy-related and HIV-related outcomes of women on ART and their infants exposed to HIV or ART in utero or via breast milk. Participants IeDEA is organised in four regions (Central, East, Southern and West Africa), with 240 treatment and care sites, six data centres at African, European and US universities, and almost 1.4 million children, adolescents and adult people living with HIV (PLWHIV) enrolled. Findings to date The data include socio-demographic characteristics, clinical outcomes, opportunistic events, treatment regimens, clinic visits and laboratory measurements. They have been used to analyse outcomes in PLWHIV-1 or PLWHIV-2 who initiate ART, including determinants of mortality, of switching to second-line and third-line ART, drug resistance, loss to follow-up and the immunological and virological response to different ART regimens. Programme-level estimates of mortality have been corrected for loss to follow-up. We examined the impact of coinfection with hepatitis B and C, and the epidemiology of different cancers and of (multidrug resistant) tuberculosis, renal disease and of mental illness. The adoption of 'Treat All', making ART available to all PLWHIV regardless of CD4+ cell count or clinical stage was another important research topic. Future plans IeDEA has formulated several research priorities for the 'Treat All' era in sub-Saharan Africa. It recently obtained funding to set up sentinel sites where additional data are prospectively collected on cardiometabolic risks factors as well as mental health and liver diseases, and is planning to create a drug resistance database.

Original languageEnglish (US)
Article numbere035246
JournalBMJ open
Volume10
Issue number5
DOIs
StatePublished - May 15 2020

Keywords

  • HIV & AIDS
  • epidemiology
  • infectious diseases
  • tuberculosis

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'International epidemiology databases to evaluate AIDS (IeDEA) in sub-Saharan Africa, 2012-2019'. Together they form a unique fingerprint.

  • Cite this

    Chammartin, F., Dao Ostinelli, C. H., Anastos, K., Jaquet, A., Brazier, E., Brown, S., Dabis, F., Davies, M. A., Duda, S. N., Malateste, K., Nash, D., Wools-Kaloustian, K., Von Groote, P. M., & Egger, M. (2020). International epidemiology databases to evaluate AIDS (IeDEA) in sub-Saharan Africa, 2012-2019. BMJ open, 10(5), [e035246]. https://doi.org/10.1136/bmjopen-2019-035246