Interleukin 6 modulates c-sis gene expression in cultured human endothelial cells

Tina M. Calderon, Jeffrey Sherman, Helen Wilkerson, Victor B. Hatcher, Joan W. Berman

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

Human vascular endothelial cells secrete platelet-derived growth factor (PDGF)-like polypeptides which may mediate some of the vascular effects in the inflammatory process. We have demonstrated that IL-6 caused a significant increase in the mRNA level of the c-sis gene (PDGF B chain) in cultured human endothelial cells. IL-1α and IL-1β also increased c-sis mRNA transcripts after an extended incubation period and both cytokines acted synergistically with IL-6 in increasing c-sis expression. Tumor necrosis factor enhanced the accumulation of c-sis mRNA and interferon-γ decreased its level. In the inflammatory process specific cytokines can modulate c-sis expression in human endothelial cells. Their subsequent production of PDGF-like polypeptides could stimulate cell migration and proliferation, and cause the release of vascular inflammatory mediators.

Original languageEnglish (US)
Pages (from-to)118-126
Number of pages9
JournalCellular Immunology
Volume143
Issue number1
DOIs
StatePublished - Aug 1992

ASJC Scopus subject areas

  • Immunology

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