Interleukin 6 modulates c-sis gene expression in cultured human endothelial cells

Tina M. Calderon, Jeffrey Sherman, Helen Wilkerson, Victor Bernard Hatcher, Joan W. Berman

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Human vascular endothelial cells secrete platelet-derived growth factor (PDGF)-like polypeptides which may mediate some of the vascular effects in the inflammatory process. We have demonstrated that IL-6 caused a significant increase in the mRNA level of the c-sis gene (PDGF B chain) in cultured human endothelial cells. IL-1α and IL-1β also increased c-sis mRNA transcripts after an extended incubation period and both cytokines acted synergistically with IL-6 in increasing c-sis expression. Tumor necrosis factor enhanced the accumulation of c-sis mRNA and interferon-γ decreased its level. In the inflammatory process specific cytokines can modulate c-sis expression in human endothelial cells. Their subsequent production of PDGF-like polypeptides could stimulate cell migration and proliferation, and cause the release of vascular inflammatory mediators.

Original languageEnglish (US)
Pages (from-to)118-126
Number of pages9
JournalCellular Immunology
Volume143
Issue number1
DOIs
StatePublished - 1992

Fingerprint

sis Genes
Interleukin-6
Endothelial Cells
Platelet-Derived Growth Factor
Interleukin-1
Gene Expression
Messenger RNA
Blood Vessels
Proto-Oncogene Proteins c-sis
Cytokines
Peptides
Interferons
Cell Movement
Tumor Necrosis Factor-alpha
Cell Proliferation

ASJC Scopus subject areas

  • Cell Biology
  • Immunology

Cite this

Interleukin 6 modulates c-sis gene expression in cultured human endothelial cells. / Calderon, Tina M.; Sherman, Jeffrey; Wilkerson, Helen; Hatcher, Victor Bernard; Berman, Joan W.

In: Cellular Immunology, Vol. 143, No. 1, 1992, p. 118-126.

Research output: Contribution to journalArticle

@article{0ac7dd1aab174eaa8024894fe6930376,
title = "Interleukin 6 modulates c-sis gene expression in cultured human endothelial cells",
abstract = "Human vascular endothelial cells secrete platelet-derived growth factor (PDGF)-like polypeptides which may mediate some of the vascular effects in the inflammatory process. We have demonstrated that IL-6 caused a significant increase in the mRNA level of the c-sis gene (PDGF B chain) in cultured human endothelial cells. IL-1α and IL-1β also increased c-sis mRNA transcripts after an extended incubation period and both cytokines acted synergistically with IL-6 in increasing c-sis expression. Tumor necrosis factor enhanced the accumulation of c-sis mRNA and interferon-γ decreased its level. In the inflammatory process specific cytokines can modulate c-sis expression in human endothelial cells. Their subsequent production of PDGF-like polypeptides could stimulate cell migration and proliferation, and cause the release of vascular inflammatory mediators.",
author = "Calderon, {Tina M.} and Jeffrey Sherman and Helen Wilkerson and Hatcher, {Victor Bernard} and Berman, {Joan W.}",
year = "1992",
doi = "10.1016/0008-8749(92)90010-M",
language = "English (US)",
volume = "143",
pages = "118--126",
journal = "Cellular Immunology",
issn = "0008-8749",
publisher = "Academic Press Inc.",
number = "1",

}

TY - JOUR

T1 - Interleukin 6 modulates c-sis gene expression in cultured human endothelial cells

AU - Calderon, Tina M.

AU - Sherman, Jeffrey

AU - Wilkerson, Helen

AU - Hatcher, Victor Bernard

AU - Berman, Joan W.

PY - 1992

Y1 - 1992

N2 - Human vascular endothelial cells secrete platelet-derived growth factor (PDGF)-like polypeptides which may mediate some of the vascular effects in the inflammatory process. We have demonstrated that IL-6 caused a significant increase in the mRNA level of the c-sis gene (PDGF B chain) in cultured human endothelial cells. IL-1α and IL-1β also increased c-sis mRNA transcripts after an extended incubation period and both cytokines acted synergistically with IL-6 in increasing c-sis expression. Tumor necrosis factor enhanced the accumulation of c-sis mRNA and interferon-γ decreased its level. In the inflammatory process specific cytokines can modulate c-sis expression in human endothelial cells. Their subsequent production of PDGF-like polypeptides could stimulate cell migration and proliferation, and cause the release of vascular inflammatory mediators.

AB - Human vascular endothelial cells secrete platelet-derived growth factor (PDGF)-like polypeptides which may mediate some of the vascular effects in the inflammatory process. We have demonstrated that IL-6 caused a significant increase in the mRNA level of the c-sis gene (PDGF B chain) in cultured human endothelial cells. IL-1α and IL-1β also increased c-sis mRNA transcripts after an extended incubation period and both cytokines acted synergistically with IL-6 in increasing c-sis expression. Tumor necrosis factor enhanced the accumulation of c-sis mRNA and interferon-γ decreased its level. In the inflammatory process specific cytokines can modulate c-sis expression in human endothelial cells. Their subsequent production of PDGF-like polypeptides could stimulate cell migration and proliferation, and cause the release of vascular inflammatory mediators.

UR - http://www.scopus.com/inward/record.url?scp=0026681517&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026681517&partnerID=8YFLogxK

U2 - 10.1016/0008-8749(92)90010-M

DO - 10.1016/0008-8749(92)90010-M

M3 - Article

C2 - 1623561

AN - SCOPUS:0026681517

VL - 143

SP - 118

EP - 126

JO - Cellular Immunology

JF - Cellular Immunology

SN - 0008-8749

IS - 1

ER -