Interleukin-10 polymorphism in position-1082 and acute respiratory distress syndrome

Michelle Ng Gong, B. T. Thompson, P. L. Williams, W. Zhou, M. Z. Wang, L. Pothier, D. C. Christiani

Research output: Contribution to journalArticle

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Abstract

The GG genotype of the interleukin (IL)-10 promoter polymorphism in position - 1082 (-1082GG) has been associated with increased IL-10 production. The current authors hypothesised that the -1082GG genotype is associated with the development of, and outcomes in, acute respiratory distress syndrome (ARDS). A nested case-control study was conducted in 211 Caucasian cases of ARDS and 429 controls who were admitted to an intensive care unit with sepsis, trauma, aspiration or massive transfusions. Cases were followed for organ failure and 60-day mortality. The -1082GG genotype was associated with the development of ARDS, but only in the presence of a significant interaction between the -1082GG genotype and age. Among patients with ARDS, the -1082GG genotype was associated with decreased severity of illness on admission, lower daily organ dysfunction scores and lower 60-day mortality. In conclusion, the high interleukin-10-producing -1082GG genotype may be associated with variable odds for acute respiratory distress syndrome development depending on age. Among those with acute respiratory distress syndrome, the -1082GG genotype is associated with lower mortality and organ failure. Further studies are needed to confirm these findings.

Original languageEnglish (US)
Pages (from-to)674-681
Number of pages8
JournalEuropean Respiratory Journal
Volume27
Issue number4
DOIs
StatePublished - Apr 2006
Externally publishedYes

Fingerprint

Adult Respiratory Distress Syndrome
Interleukin-10
Genotype
Mortality
Organ Dysfunction Scores
Intensive Care Units
Case-Control Studies
Sepsis
Wounds and Injuries

Keywords

  • Acute respiratory distress syndrome
  • Interleukin-10
  • Mortality
  • Polymorphism

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Gong, M. N., Thompson, B. T., Williams, P. L., Zhou, W., Wang, M. Z., Pothier, L., & Christiani, D. C. (2006). Interleukin-10 polymorphism in position-1082 and acute respiratory distress syndrome. European Respiratory Journal, 27(4), 674-681. https://doi.org/10.1183/09031936.06.00046405

Interleukin-10 polymorphism in position-1082 and acute respiratory distress syndrome. / Gong, Michelle Ng; Thompson, B. T.; Williams, P. L.; Zhou, W.; Wang, M. Z.; Pothier, L.; Christiani, D. C.

In: European Respiratory Journal, Vol. 27, No. 4, 04.2006, p. 674-681.

Research output: Contribution to journalArticle

Gong, MN, Thompson, BT, Williams, PL, Zhou, W, Wang, MZ, Pothier, L & Christiani, DC 2006, 'Interleukin-10 polymorphism in position-1082 and acute respiratory distress syndrome', European Respiratory Journal, vol. 27, no. 4, pp. 674-681. https://doi.org/10.1183/09031936.06.00046405
Gong, Michelle Ng ; Thompson, B. T. ; Williams, P. L. ; Zhou, W. ; Wang, M. Z. ; Pothier, L. ; Christiani, D. C. / Interleukin-10 polymorphism in position-1082 and acute respiratory distress syndrome. In: European Respiratory Journal. 2006 ; Vol. 27, No. 4. pp. 674-681.
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