Abstract
We have studied the possible role of interleukin-1 (IL-1) on the interleukin-2 (IL-2) dependent development of mouse natural killer (NK) cells from primitive bone marrow (BM) precursors. Results indicate that both IL-1α and IL-1̄ (1-10 U/ml) are able to stimulate the generation of NK cells from 5-fluorouracil (5-FU) resistant BM progenitors. These precursor cells are asialoGM1-, Thy-1+, Lyt-1- and Lyt-2-. Effector cells generated by culturing with IL-2 (40 U/ml) and IL-1 (5 U/ml) are Thy-1+, asialoGM1+, Lyt-5+, Lyt-1-, Lyt-2- and lyse only NK-susceptible targets. Generation of NK cells is blocked by addition of anti-IL-2/r. These data indicate that IL-1 may play a role in the generation of mature NK cells from undifferentiated BM precursors.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 306-315 |
| Number of pages | 10 |
| Journal | Natural Immunity and Cell Growth Regulation |
| Volume | 6 |
| Issue number | 6 |
| State | Published - 1987 |
ASJC Scopus subject areas
- Immunology
- Clinical Biochemistry