Interleukin-1 augments the interleukin-2-dependent generation of natural killer cells from bone marrow precursors

G. Migliorati, L. Cannarile, L. D'Adamio, R. B. Herberman, C. Riccardi

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Abstract

We have studied the possible role of interleukin-1 (IL-1) on the interleukin-2 (IL-2) dependent development of mouse natural killer (NK) cells from primitive bone marrow (BM) precursors. Results indicate that both IL-1α and IL-1̄ (1-10 U/ml) are able to stimulate the generation of NK cells from 5-fluorouracil (5-FU) resistant BM progenitors. These precursor cells are asialoGM1-, Thy-1+, Lyt-1- and Lyt-2-. Effector cells generated by culturing with IL-2 (40 U/ml) and IL-1 (5 U/ml) are Thy-1+, asialoGM1+, Lyt-5+, Lyt-1-, Lyt-2- and lyse only NK-susceptible targets. Generation of NK cells is blocked by addition of anti-IL-2/r. These data indicate that IL-1 may play a role in the generation of mature NK cells from undifferentiated BM precursors.

Original languageEnglish (US)
Pages (from-to)306-315
Number of pages10
JournalNatural Immunity and Cell Growth Regulation
Volume6
Issue number6
Publication statusPublished - Dec 1 1987

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ASJC Scopus subject areas

  • Immunology
  • Clinical Biochemistry

Cite this

Migliorati, G., Cannarile, L., D'Adamio, L., Herberman, R. B., & Riccardi, C. (1987). Interleukin-1 augments the interleukin-2-dependent generation of natural killer cells from bone marrow precursors. Natural Immunity and Cell Growth Regulation, 6(6), 306-315.