Interfering with apoptosis

Ca2+-binding protein ALG-2 and Alzheimer's disease gene ALG-3

Pasquale Vito, Emanuela Lacaná, Luciano D'Adamio

Research output: Contribution to journalArticle

435 Citations (Scopus)

Abstract

Two apoptosis-linked genes, named ALG-2 and ALG-3, were identified by means of a functional selection strategy. ALG-2 codes for a Ca2+-binding protein required for T cell receptor-, Fas-, and glucocorticoid-induced cell death. ALG-3, a partial complementary DNA that is homologous to the familial Alzheimer's disease gene STM2, rescues a T cell hybridoma from T cell receptor- and Fas-induced apoptosis. These findings suggest that ALG-2 may mediate Ca2+-regulated signals along the death pathway and that cell death may play a role in Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)521-525
Number of pages5
JournalScience
Volume271
Issue number5248
StatePublished - Jan 26 1996
Externally publishedYes

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T-Cell Antigen Receptor
Carrier Proteins
Alzheimer Disease
Cell Death
Apoptosis
Hybridomas
Glucocorticoids
Genes
Complementary DNA
T-Lymphocytes
Alzheimer disease type 2

ASJC Scopus subject areas

  • General

Cite this

Vito, P., Lacaná, E., & D'Adamio, L. (1996). Interfering with apoptosis: Ca2+-binding protein ALG-2 and Alzheimer's disease gene ALG-3. Science, 271(5248), 521-525.

Interfering with apoptosis : Ca2+-binding protein ALG-2 and Alzheimer's disease gene ALG-3. / Vito, Pasquale; Lacaná, Emanuela; D'Adamio, Luciano.

In: Science, Vol. 271, No. 5248, 26.01.1996, p. 521-525.

Research output: Contribution to journalArticle

Vito, P, Lacaná, E & D'Adamio, L 1996, 'Interfering with apoptosis: Ca2+-binding protein ALG-2 and Alzheimer's disease gene ALG-3', Science, vol. 271, no. 5248, pp. 521-525.
Vito P, Lacaná E, D'Adamio L. Interfering with apoptosis: Ca2+-binding protein ALG-2 and Alzheimer's disease gene ALG-3. Science. 1996 Jan 26;271(5248):521-525.
Vito, Pasquale ; Lacaná, Emanuela ; D'Adamio, Luciano. / Interfering with apoptosis : Ca2+-binding protein ALG-2 and Alzheimer's disease gene ALG-3. In: Science. 1996 ; Vol. 271, No. 5248. pp. 521-525.
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