Interfering with apoptosis: Ca2+-binding protein ALG-2 and Alzheimer's disease gene ALG-3

Pasquale Vito, Emanuela Lacaná, Luciano D'Adamio

Research output: Contribution to journalArticle

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Abstract

Two apoptosis-linked genes, named ALG-2 and ALG-3, were identified by means of a functional selection strategy. ALG-2 codes for a Ca2+-binding protein required for T cell receptor-, Fas-, and glucocorticoid-induced cell death. ALG-3, a partial complementary DNA that is homologous to the familial Alzheimer's disease gene STM2, rescues a T cell hybridoma from T cell receptor- and Fas-induced apoptosis. These findings suggest that ALG-2 may mediate Ca2+-regulated signals along the death pathway and that cell death may play a role in Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)521-525
Number of pages5
JournalScience
Volume271
Issue number5248
DOIs
StatePublished - Jan 26 1996

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