TY - JOUR
T1 - Interfering with apoptosis
T2 - Ca2+-binding protein ALG-2 and Alzheimer's disease gene ALG-3
AU - Vito, Pasquale
AU - Lacaná, Emanuela
AU - D'Adamio, Luciano
PY - 1996/1/26
Y1 - 1996/1/26
N2 - Two apoptosis-linked genes, named ALG-2 and ALG-3, were identified by means of a functional selection strategy. ALG-2 codes for a Ca2+-binding protein required for T cell receptor-, Fas-, and glucocorticoid-induced cell death. ALG-3, a partial complementary DNA that is homologous to the familial Alzheimer's disease gene STM2, rescues a T cell hybridoma from T cell receptor- and Fas-induced apoptosis. These findings suggest that ALG-2 may mediate Ca2+-regulated signals along the death pathway and that cell death may play a role in Alzheimer's disease.
AB - Two apoptosis-linked genes, named ALG-2 and ALG-3, were identified by means of a functional selection strategy. ALG-2 codes for a Ca2+-binding protein required for T cell receptor-, Fas-, and glucocorticoid-induced cell death. ALG-3, a partial complementary DNA that is homologous to the familial Alzheimer's disease gene STM2, rescues a T cell hybridoma from T cell receptor- and Fas-induced apoptosis. These findings suggest that ALG-2 may mediate Ca2+-regulated signals along the death pathway and that cell death may play a role in Alzheimer's disease.
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U2 - 10.1126/science.271.5248.521
DO - 10.1126/science.271.5248.521
M3 - Article
C2 - 8560270
AN - SCOPUS:0029671219
SN - 0036-8075
VL - 271
SP - 521
EP - 525
JO - Science
JF - Science
IS - 5248
ER -