Intercontinental spread from Israel to Colombia of a KPC- 3- producing Klebsiella pneumoniae strain

J. A. Lopez, A. Correa, S. Navon- Venezia, A. L. Correa, Julian A. Torres Isasiga, D. F. Briceño, M. C. Montealegre, J. P. Quinn, Y. Carmeli, M. V. Villegas

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

In 2008, an increase in the prevalence of carbapenem- resistant Klebsiella pneumoniae was noted in a 286- bed tertiary case hospital in Colombia, where 84 patients (32 infected and 52 colonized) had positive cultures. The identified index patient came from Israel for a liver transplantation. High level carbapenem resistance was observed. Polymyxin B and tigecycline were the only two antibiotics that remained active. PCR- restriction fragment length polymorphism analysis and sequencing revealed blaKPC- 3 in the major clone, which was indistinguishable from the K. pneumoniae carbapenemase- 3- producing clone described previously in Israel. This exemplifies the threat posed by the global spread of K. pneumoniae carbapenemase- producing pathogens.

Original languageEnglish (US)
Pages (from-to)52-56
Number of pages5
JournalClinical Microbiology and Infection
Volume17
Issue number1
DOIs
StatePublished - Jan 1 2011
Externally publishedYes

Fingerprint

Colombia
Klebsiella pneumoniae
Israel
Carbapenems
Clone Cells
Polymyxin B
Tertiary Care Centers
Restriction Fragment Length Polymorphisms
Liver Transplantation
Anti-Bacterial Agents
Polymerase Chain Reaction
carbapenemase

Keywords

  • Colombia
  • Dissemination
  • Israel
  • Klebsiella pneumoniae
  • KPC- 3

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Intercontinental spread from Israel to Colombia of a KPC- 3- producing Klebsiella pneumoniae strain. / Lopez, J. A.; Correa, A.; Navon- Venezia, S.; Correa, A. L.; Torres Isasiga, Julian A.; Briceño, D. F.; Montealegre, M. C.; Quinn, J. P.; Carmeli, Y.; Villegas, M. V.

In: Clinical Microbiology and Infection, Vol. 17, No. 1, 01.01.2011, p. 52-56.

Research output: Contribution to journalArticle

Lopez, JA, Correa, A, Navon- Venezia, S, Correa, AL, Torres Isasiga, JA, Briceño, DF, Montealegre, MC, Quinn, JP, Carmeli, Y & Villegas, MV 2011, 'Intercontinental spread from Israel to Colombia of a KPC- 3- producing Klebsiella pneumoniae strain', Clinical Microbiology and Infection, vol. 17, no. 1, pp. 52-56. https://doi.org/10.1111/j.1469-0691.2010.03209.x
Lopez, J. A. ; Correa, A. ; Navon- Venezia, S. ; Correa, A. L. ; Torres Isasiga, Julian A. ; Briceño, D. F. ; Montealegre, M. C. ; Quinn, J. P. ; Carmeli, Y. ; Villegas, M. V. / Intercontinental spread from Israel to Colombia of a KPC- 3- producing Klebsiella pneumoniae strain. In: Clinical Microbiology and Infection. 2011 ; Vol. 17, No. 1. pp. 52-56.
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