Intercontinental spread from Israel to Colombia of a KPC- 3- producing Klebsiella pneumoniae strain

J. A. Lopez, A. Correa, S. Navon- Venezia, A. L. Correa, J. A. Torres, D. F. Briceño, M. C. Montealegre, J. P. Quinn, Y. Carmeli, M. V. Villegas

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Abstract

In 2008, an increase in the prevalence of carbapenem- resistant Klebsiella pneumoniae was noted in a 286- bed tertiary case hospital in Colombia, where 84 patients (32 infected and 52 colonized) had positive cultures. The identified index patient came from Israel for a liver transplantation. High level carbapenem resistance was observed. Polymyxin B and tigecycline were the only two antibiotics that remained active. PCR- restriction fragment length polymorphism analysis and sequencing revealed blaKPC- 3 in the major clone, which was indistinguishable from the K. pneumoniae carbapenemase- 3- producing clone described previously in Israel. This exemplifies the threat posed by the global spread of K. pneumoniae carbapenemase- producing pathogens.

Original languageEnglish (US)
Pages (from-to)52-56
Number of pages5
JournalClinical Microbiology and Infection
Volume17
Issue number1
DOIs
Publication statusPublished - Jan 2011

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Keywords

  • Colombia
  • Dissemination
  • Israel
  • KPC- 3
  • Klebsiella pneumoniae

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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