Intercalary heterochromatin in Drosophila melanogaster polytene chromosomes and the problem of genetic silencing

Igor F. Zhimulev, Elena S. Belyaeva, Igor V. Makunin, Vincenzo Pirrotta, Valery F. Semeshin, Artyom A. Alekseyenko, Stepan N. Belyakin, Elena I. Volkova, Dmitry E. Koryakov, Evgeniya N. Andreyeva, Olga V. Demakova, Irina V. Kotlikova, Tatyana D. Kolesnikova, Lidiya V. Boldyreva, Roman A. Nanayev

Research output: Contribution to journalReview article

14 Scopus citations

Abstract

The morphological characteristics of intercalary heterochromatin (IH) are compared with those of other types of silenced chromatin in the Drosophila melanogaster genome: pericentric heterochromatin (PH) and regions subject to position effect variegation (PEV). We conclude that IH regions in polytene chromosomes are binding sites of silencing complexes such as PcG complexes and of SuUR protein. Binding of these proteins results in the appearance of condensed chromatin and late replication of DNA, which in turn may result in DNA underreplication. IH and PH as well as regions subject to PEV have in common the condensed chromatin appearance, the localization of specific proteins, late replication, underreplication in polytene chromosomes, and ectopic pairing.

Original languageEnglish (US)
Pages (from-to)259-270
Number of pages12
JournalGenetica
Volume117
Issue number2-3
DOIs
StatePublished - Mar 1 2003
Externally publishedYes

Keywords

  • Epigenetic silencing
  • Intercalary heterochromatin
  • Pericentric heterochromatin
  • Position effect variegation
  • SuUR

ASJC Scopus subject areas

  • Animal Science and Zoology
  • Genetics
  • Plant Science
  • Insect Science

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  • Cite this

    Zhimulev, I. F., Belyaeva, E. S., Makunin, I. V., Pirrotta, V., Semeshin, V. F., Alekseyenko, A. A., Belyakin, S. N., Volkova, E. I., Koryakov, D. E., Andreyeva, E. N., Demakova, O. V., Kotlikova, I. V., Kolesnikova, T. D., Boldyreva, L. V., & Nanayev, R. A. (2003). Intercalary heterochromatin in Drosophila melanogaster polytene chromosomes and the problem of genetic silencing. Genetica, 117(2-3), 259-270. https://doi.org/10.1023/A:1022912716376