Interactions of amidated acids with heparin

Ruel Z.B. Desamero, Hu Cheng, Sean Cahill, Mark Girvin, Hua Deng, Robert Callender, Parshuram Rath, Bruce Variano, John E. Smart

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

Raman and NMR studies are performed to characterize the solution structures of complexes between heparin and a group of amidated acids, which act as delivery agents that facilitate the gastrointestinal absorption of orally administered heparin. At concentrations typically employed for the oral drug delivery of heparin, the contact points between heparin complexed with the delivery agents include points near the OH groups of heparin. The results suggest that heparin interacts rather nonspecifically with the amidated acids as monomers and with self-associated complexes of the delivery agents. It is also found that the carboxyl groups of at least one of the bioactive delivery agents easily protonates when it forms complexes with itself or heparin. This attribute may be one reason why this class of compounds is effective in the oral delivery of heparin.

Original languageEnglish (US)
Pages (from-to)41-48
Number of pages8
JournalBiopolymers - Biospectroscopy Section
Volume67
Issue number1
DOIs
Publication statusPublished - Feb 23 2002

    Fingerprint

Keywords

  • Amidated acids
  • Heparin
  • Oral drug delivery

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Biomaterials
  • Organic Chemistry

Cite this

Desamero, R. Z. B., Cheng, H., Cahill, S., Girvin, M., Deng, H., Callender, R., ... Smart, J. E. (2002). Interactions of amidated acids with heparin. Biopolymers - Biospectroscopy Section, 67(1), 41-48. https://doi.org/10.1002/bip.10040