Interactions between proteins bound to the duck βA-globin gene promoter and enhancer detected by the DNaseI footprinting

Aleš Cvekl, Václav Pačes

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The duck βA-globin (βAGLB) enhancer was closely linked to the duck βA-GLB promoter, and the construct was used to study binding of nuclear proteins to specific sites of these regulatory elements. DNaseI-footprint analysis showed that the presence of the enhancer induced binding of proteins to additional sites on the promoter. The results are consistent with the looping-out model, based on specific interactions of enhancer-bound and promoter bound-proteins.

Original languageEnglish (US)
Pages (from-to)225-228
Number of pages4
JournalGene
Volume110
Issue number2
DOIs
StatePublished - Jan 15 1992
Externally publishedYes

Keywords

  • Avian globin-encoding genes
  • DNA looping
  • recombinant DNA
  • transcription factors

ASJC Scopus subject areas

  • Genetics

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