Interactions between gastric volume and duodenal nutrients in the control of liquid gastric emptying

Timothy H. Moran, James B. Wirth, Gary J. Schwartz, Paul R. McHugh

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

We examined the relationships between gastric volume and duodenal glucose load in the regulation of gastric emptying in adult male rhesus monkeys. Intragastric glucose loads (0.125 g/ml) of volumes ranging from 150 to 375 ml empty from the stomach at the same rate from 20 to 120 min. However, to achieve these equivalent emptying rates, progressively larger volumes were emptied in the initial 20 min with increasing gastric volume. Duodenal glucose infusions dose dependently inhibited the 10-min emptying of various volumes of intragastric saline. Although increasing gastric volume resulted in increased emptying, duodenal glucose right-shifted the relationship between initial gastric volume and volume emptied. These data demonstrate that liquid nutrient gastric emptying represents an interaction between gastric volume and nutrient-induced duodenal feedback. For controlled duodenal caloric delivery rates to be established, sufficient nutrient emptying must occur to increase the magnitude of duodenal feedback to withhold a given gastric volume.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume276
Issue number4 45-4
StatePublished - Apr 1999
Externally publishedYes

Fingerprint

Gastric Emptying
Stomach
Food
Glucose
Macaca mulatta

Keywords

  • Duodenal feedback
  • Glucose
  • Rhesus monkeys
  • Stomach

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Interactions between gastric volume and duodenal nutrients in the control of liquid gastric emptying. / Moran, Timothy H.; Wirth, James B.; Schwartz, Gary J.; McHugh, Paul R.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 276, No. 4 45-4, 04.1999.

Research output: Contribution to journalArticle

@article{88bf747387a4436db3cd50e25fe4a9b1,
title = "Interactions between gastric volume and duodenal nutrients in the control of liquid gastric emptying",
abstract = "We examined the relationships between gastric volume and duodenal glucose load in the regulation of gastric emptying in adult male rhesus monkeys. Intragastric glucose loads (0.125 g/ml) of volumes ranging from 150 to 375 ml empty from the stomach at the same rate from 20 to 120 min. However, to achieve these equivalent emptying rates, progressively larger volumes were emptied in the initial 20 min with increasing gastric volume. Duodenal glucose infusions dose dependently inhibited the 10-min emptying of various volumes of intragastric saline. Although increasing gastric volume resulted in increased emptying, duodenal glucose right-shifted the relationship between initial gastric volume and volume emptied. These data demonstrate that liquid nutrient gastric emptying represents an interaction between gastric volume and nutrient-induced duodenal feedback. For controlled duodenal caloric delivery rates to be established, sufficient nutrient emptying must occur to increase the magnitude of duodenal feedback to withhold a given gastric volume.",
keywords = "Duodenal feedback, Glucose, Rhesus monkeys, Stomach",
author = "Moran, {Timothy H.} and Wirth, {James B.} and Schwartz, {Gary J.} and McHugh, {Paul R.}",
year = "1999",
month = "4",
language = "English (US)",
volume = "276",
journal = "American Journal of Physiology - Renal Fluid and Electrolyte Physiology",
issn = "1931-857X",
publisher = "American Physiological Society",
number = "4 45-4",

}

TY - JOUR

T1 - Interactions between gastric volume and duodenal nutrients in the control of liquid gastric emptying

AU - Moran, Timothy H.

AU - Wirth, James B.

AU - Schwartz, Gary J.

AU - McHugh, Paul R.

PY - 1999/4

Y1 - 1999/4

N2 - We examined the relationships between gastric volume and duodenal glucose load in the regulation of gastric emptying in adult male rhesus monkeys. Intragastric glucose loads (0.125 g/ml) of volumes ranging from 150 to 375 ml empty from the stomach at the same rate from 20 to 120 min. However, to achieve these equivalent emptying rates, progressively larger volumes were emptied in the initial 20 min with increasing gastric volume. Duodenal glucose infusions dose dependently inhibited the 10-min emptying of various volumes of intragastric saline. Although increasing gastric volume resulted in increased emptying, duodenal glucose right-shifted the relationship between initial gastric volume and volume emptied. These data demonstrate that liquid nutrient gastric emptying represents an interaction between gastric volume and nutrient-induced duodenal feedback. For controlled duodenal caloric delivery rates to be established, sufficient nutrient emptying must occur to increase the magnitude of duodenal feedback to withhold a given gastric volume.

AB - We examined the relationships between gastric volume and duodenal glucose load in the regulation of gastric emptying in adult male rhesus monkeys. Intragastric glucose loads (0.125 g/ml) of volumes ranging from 150 to 375 ml empty from the stomach at the same rate from 20 to 120 min. However, to achieve these equivalent emptying rates, progressively larger volumes were emptied in the initial 20 min with increasing gastric volume. Duodenal glucose infusions dose dependently inhibited the 10-min emptying of various volumes of intragastric saline. Although increasing gastric volume resulted in increased emptying, duodenal glucose right-shifted the relationship between initial gastric volume and volume emptied. These data demonstrate that liquid nutrient gastric emptying represents an interaction between gastric volume and nutrient-induced duodenal feedback. For controlled duodenal caloric delivery rates to be established, sufficient nutrient emptying must occur to increase the magnitude of duodenal feedback to withhold a given gastric volume.

KW - Duodenal feedback

KW - Glucose

KW - Rhesus monkeys

KW - Stomach

UR - http://www.scopus.com/inward/record.url?scp=0032929614&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032929614&partnerID=8YFLogxK

M3 - Article

VL - 276

JO - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

JF - American Journal of Physiology - Renal Fluid and Electrolyte Physiology

SN - 1931-857X

IS - 4 45-4

ER -