Interaction between tobacco and alcohol consumption and the risk of cancers of the upper aero-digestive tract in Brazil

Nicolas F. Schlecht, Eduardo L. Franco, Javier Pintos, Abdissa Negassa, Luiz P. Kowalski, Benedito V. Oliveira, Maria P. Curado

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

The authors investigated the joint effects of tobacco and alcohol consumption on the risk of squamous cell carcinomas of the upper aero- digestive tract (UADT) using data from a hospital-based case-control study conducted in southern Brazil, 1986-1989. A total of 784 cases of cancers of the mouth, pharynx, and larynx and 1,578 non-cancer controls matched on age, sex, hospital catchment area, and period of admission were interviewed about their smoking and drinking habits and other characteristics. Using logistic regression, evidence was found for interaction between the cumulative exposures for smoking and alcohol on UADT cancer risk. The joint effects for pharyngeal cancers exceeded the levels expected under a multiplicative model for moderate smokers (p = 0.007). There was little statistical evidence, however, for interaction on cancers of the mouth (p = 0.28) or larynx (p = 0.95). Among never smokers, heavy drinkers had 9.2 times (95% confidence interval 1.7, 48.5) greater risk of cancers of mouth, pharynx, and supraglottis than never drinkers, with a dose-response trend (p = 0.013) with cumulative consumption. The authors conclude that the interaction occurring in the pharynx between smoking and alcohol on UADT cancers is not uniform, with varying effects depending on the level of smoking exposure. Alcohol may act as both a promoter for tobacco and as an independent risk factor.

Original languageEnglish (US)
Pages (from-to)1129-1137
Number of pages9
JournalAmerican Journal of Epidemiology
Volume150
Issue number11
StatePublished - Dec 1 1999
Externally publishedYes

Fingerprint

Pharyngeal Neoplasms
Tobacco Use
Alcohol Drinking
Brazil
Gastrointestinal Tract
Mouth Neoplasms
Smoking
Alcohols
Neoplasms
Laryngeal Neoplasms
Larynx
Pharynx
Drinking
Habits
Tobacco
Case-Control Studies
Squamous Cell Carcinoma
Logistic Models
Confidence Intervals

Keywords

  • Alcohol drinking
  • Case-control studies
  • Epidemiologic methods
  • Head and neck neoplasms
  • Larynx
  • Mouth
  • Pharynx
  • Smoking

ASJC Scopus subject areas

  • Epidemiology

Cite this

Schlecht, N. F., Franco, E. L., Pintos, J., Negassa, A., Kowalski, L. P., Oliveira, B. V., & Curado, M. P. (1999). Interaction between tobacco and alcohol consumption and the risk of cancers of the upper aero-digestive tract in Brazil. American Journal of Epidemiology, 150(11), 1129-1137.

Interaction between tobacco and alcohol consumption and the risk of cancers of the upper aero-digestive tract in Brazil. / Schlecht, Nicolas F.; Franco, Eduardo L.; Pintos, Javier; Negassa, Abdissa; Kowalski, Luiz P.; Oliveira, Benedito V.; Curado, Maria P.

In: American Journal of Epidemiology, Vol. 150, No. 11, 01.12.1999, p. 1129-1137.

Research output: Contribution to journalArticle

Schlecht, NF, Franco, EL, Pintos, J, Negassa, A, Kowalski, LP, Oliveira, BV & Curado, MP 1999, 'Interaction between tobacco and alcohol consumption and the risk of cancers of the upper aero-digestive tract in Brazil', American Journal of Epidemiology, vol. 150, no. 11, pp. 1129-1137.
Schlecht, Nicolas F. ; Franco, Eduardo L. ; Pintos, Javier ; Negassa, Abdissa ; Kowalski, Luiz P. ; Oliveira, Benedito V. ; Curado, Maria P. / Interaction between tobacco and alcohol consumption and the risk of cancers of the upper aero-digestive tract in Brazil. In: American Journal of Epidemiology. 1999 ; Vol. 150, No. 11. pp. 1129-1137.
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